Cell-Penetrating Peptides: A Challenge for Drug Delivery
Sonia Aroui,Abderraouf Kenani +1 more
TLDR
An overview of the current approaches and the potential of CPP-based drug delivery systems are described and their powerful promise for clinical efficacy is indicated.Abstract:
Cell-penetrating peptide (CPP) is a term that describes relatively short amphipathic and cationic peptides (7–30 amino acid residues) with rapid translocation across the cell membrane. They can be used to deliver molecular bioactive cargoes due to their efficacy in cellular internalization and also to their low cytotoxicity. In this review we provide an overview of the current approaches and describe the potential of CPP-based drug delivery systems and indicate their powerful promise for clinical efficacy.read more
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Cyclodextrins-Peptides/Proteins Conjugates: Synthesis, Properties and Applications.
TL;DR: In this paper, a family of macrocyclic oligosaccharides called cyclodextrins (CDs) with peptide/protein conjugation was studied.
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Cell-Penetrating Peptides (CPPs) as Therapeutic and Diagnostic Agents for Cancer
Ryan A. Bottens,Tohru Yamada +1 more
TL;DR: The role of CPPs as permeation enhancers for targeted drug delivery applications is discussed in this article , where the authors highlight targeted delivery and explore the potential uses for CMPs as diagnostics, drug delivery, and intrinsic anti-cancer agents.
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Biophysical Characterization of LTX-315 Anticancer Peptide Interactions with Model Membrane Platforms: Effect of Membrane Surface Charge
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References
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TL;DR: A review focused on uptake mechanisms used by CPPs for membrane translocation and certain experimental factors that affect the mechanism(s) are given.
Journal ArticleDOI
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