Journal ArticleDOI
Characterization of swine isolates of Clostridium difficile in Spain: a potential source of epidemic multidrug resistant strains?
Teresa Peláez,Luis Alcalá,José L. Blanco,Sergio Álvarez-Pérez,Mercedes Marín,Mercedes Marín,Adoración Martín-López,Pilar Catalán,Elena Reigadas,Marta E. Garcia,Emilio Bouza,Emilio Bouza +11 more
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TLDR
The results show a high prevalence of the toxigenic 078 ribotype and multidrug resistance and metronidazole heteroresistance was found among animal isolates of C. difficile in swine in Spain, highlighting the role of livestock as a potential source of epidemic multidrog resistant strains in Spain.About:
This article is published in Anaerobe.The article was published on 2013-08-01. It has received 52 citations till now. The article focuses on the topics: Etest & Multiple drug resistance.read more
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Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection.
TL;DR: Investigations of the fitness cost in C. difficile indicate that both genetic elements and mutations in the molecular targets of antibiotics can be maintained regardless of the burden imposed on fitness, suggesting that resistances may persist in the C. Difficile population also in absence of antibiotic selective pressure.
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Understanding Clostridium difficile Colonization
Monique J. T. Crobach,Jonathan Vernon,Vivian G. Loo,Ling Yuan Kong,Séverine Péchiné,Mark H. Wilcox,Ed J. Kuijper +6 more
TL;DR: A comprehensive overview of the current understanding of C. difficile colonization among patients at admission is presented, although further research is needed to identify if interventions are beneficial for preventing transmission or overcoming progression to CDI.
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Clostridium difficile infection following systemic antibiotic administration in randomised controlled trials: a systematic review and meta-analysis
TL;DR: Data from RCTs showed that clindamycin and carbapenems were associated with more CDI episodes than other antibiotics.
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A Role for Tetracycline Selection in Recent Evolution of Agriculture-Associated Clostridium difficile PCR Ribotype 078.
Kate E. Dingle,Kate E. Dingle,Xavier Didelot,P Quan,P Quan,David W Eyre,David W Eyre,Nicole Stoesser,Nicole Stoesser,Charis Marwick,John E. Coia,Derek J. Brown,Sarah Buchanan,Umer Zeeshan Ijaz,Cosmika Goswami,Gillian Douce,Warren N. Fawley,Mark H. Wilcox,Tim E. A. Peto,Tim E. A. Peto,A. Sarah Walker,A. Sarah Walker,Derrick W. Crook,Derrick W. Crook +23 more
TL;DR: The work indicates that the use of antimicrobials outside the health care environment has selected for resistant organisms, and in the case of RT078, has contributed to the emergence of a human pathogen.
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Dissemination of Clostridium difficile in food and the environment: Significant sources of C. difficile community-acquired infection?
TL;DR: Effective control can be exercised by reducing the environmental burden of C. difficile along with boosting the host defences against the virulent enteric pathogen, according to the host microbiome and functioning immune system.
References
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R: A language and environment for statistical computing.
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
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Clostridium difficile infection: new developments in epidemiology and pathogenesis
TL;DR: Since 2001, the prevalence and severity of C. difficile infection has increased significantly, which has led to increased research interest and the discovery of new virulence factors, and has expanded and focused the development of new treatment and prevention regimens.
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Clostridium difficile — More Difficult Than Ever
Ciaran P. Kelly,J. Thomas Lamont +1 more
TL;DR: Recent changes in the epidemiology of C. difficile have become both more prevalent and more virulent and the use of new antibiotics, probiotics, immunotherapy, and even bacteriotherapy is discussed.
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Clostridium difficile infection in Europe: a hospital-based survey
Martijn P. Bauer,Daan W. Notermans,Birgit H. B. van Benthem,Jon S. Brazier,Mark H. Wilcox,Maja Rupnik,Dominique L Monnet,Jaap T. van Dissel,Ed J. Kuijper +8 more
TL;DR: The data emphasise the importance of multicountry surveillance to detect and control C difficile infection in Europe and build capacity for diagnosis and surveillance.
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Emergence of Clostridium difficile‐associated disease in North America and Europe
TL;DR: The clinical spectrum of Clostridium difficile-associated disease (CDAD) ranges from diarrhoea to severe life-threatening pseudomembranous colitis, and is recognised increasingly in a variety of animal species and in individuals previously not considered to be predisposed.