Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation.
TLDR
The respective contributions of specific DNA lesions to the biological effects of low molecular weight alkylating agents are described.Abstract:
The reaction of DNA-damaging agents with the genome results in a plethora of lesions, commonly referred to as adducts. Adducts may cause DNA to mutate, they may represent the chemical precursors of lethal events and they can disrupt expression of genes. Determination of which adduct is responsible for each of these biological endpoints is difficult, but this task has been accomplished for some carcinogenic DNA-damaging agents. Here, we describe the respective contributions of specific DNA lesions to the biological effects of low molecular weight alkylating agents.read more
Citations
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Balancing repair and tolerance of DNA damage caused by alkylating agents
TL;DR: In this article, the response of an individual to alkylating agents can vary considerably from tissue to tissue and from person to person, pointing to genetic and epigenetic mechanisms that modulate alkylation agent toxicity.
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β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity
Arnaud Gutierrez,Luisa Laureti,S. Crussard,Heni Abida,Alexandro Rodríguez-Rojas,Jesús Blázquez,Zeynep Baharoglu,Didier Mazel,F. Darfeuille,Jörg Vogel,Ivan Matic +10 more
TL;DR: It is shown that mutagenesis induced by subinhibitory concentrations of antibiotics is a genetically controlled process that should be taken into consideration for the development of more efficient antimicrobial therapeutic strategies.
Journal ArticleDOI
DNA damage by reactive species: Mechanisms, mutation and repair
TL;DR: This review provides an overview of different guanine lesions formed due to reactions of Guanine with different reactive species, including involvement of these lesions in inter- and intra-strand crosslinks, DNA–protein crosslinks and mutagenesis.
Journal ArticleDOI
The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond
TL;DR: This minireview presents an overview of the AlkB proteins including recent data on homologs, structural features, substrate specificities, and experimental strategies for studying DNA repair by AlkB family proteins.
Journal ArticleDOI
DNA damage and repair in plants - from models to crops.
Vasilissa Manova,Damian Gruszka +1 more
TL;DR: Enhanced understanding of DNA repair processes in plants will inform and accelerate the engineering of crop genomes via both traditional and targeted approaches.
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate–Dependent Nucleic Acid Demethylase
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