Journal ArticleDOI
Chitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoin.
Daniela M. Ridolfi,Priscyla D. Marcato,Giselle Z. Justo,Giselle Z. Justo,Lívia Cordi,Daisy Maria Machado,Nelson Durán,Nelson Durán +7 more
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TLDR
The SLN-chitosan-TRE exhibited high encapsulation efficiency, high physical stability in the tested period, were not cytotoxic to keratinocytes and showed high antibacterial activity against P. acnes and S. aureus.About:
This article is published in Colloids and Surfaces B: Biointerfaces.The article was published on 2012-05-01. It has received 154 citations till now. The article focuses on the topics: Solid lipid nanoparticle.read more
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The newest achievements in synthesis, immobilization and practical applications of antibacterial nanoparticles
TL;DR: In this article, a review describes recent developments in the synthesis, modification and practical applications of nanoparticles (NPs) and also describes the methods of NPs incorporation in various matrices.
Journal ArticleDOI
Nanoparticles and nanofibers for topical drug delivery.
TL;DR: This review provides the first comprehensive overview of the use of both nanoparticles and nanofibers for topical drug delivery and provides significant evidence that this area of research has - and will continue to have - a profound impact on both clinical outcomes and the development of new products.
Journal ArticleDOI
Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: A review
Arash Moeini,Parisa Pedram,Parisa Pedram,Pooyan Makvandi,Mario Malinconico,Giovanna Gomez d'Ayala +5 more
TL;DR: Almost all studies regarding natural compounds applications in wound healing by focusing on the chitosan-based bioactive wound dressing systems are collected, and the influence of bioactive compounds on their wound healing properties are reported.
Journal ArticleDOI
Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting
Brian C. Palmer,Lisa A. DeLouise +1 more
TL;DR: The current state of nanoparticle skin delivery systems with special emphasis on targeting skin diseases is reviewed and it is shown that this technology has the potential to expand the use of transdermal routes of administration to a wide array of therapeutics.
Journal ArticleDOI
Chitosan-based nanosystems and their exploited antimicrobial activity.
Diego Romano Perinelli,Laura Fagioli,Raffaella Campana,Jenny K.W. Lam,Wally Baffone,Giovanni Filippo Palmieri,Luca Casettari,Giulia Bonacucina +7 more
TL;DR: This review aims to provide an overview on the different approaches that exploit the antimicrobial activity of chitosan‐based nanosystems and their applications, and highlight the latest advances in this field.
References
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Journal ArticleDOI
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
Journal ArticleDOI
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
Journal ArticleDOI
Antibacterial activity of chitosans and chitosan oligomers with different molecular weights.
TL;DR: Antibacterial activities of chitosan was inversely affected by pH (pH 4.5-5.9 range tested), with higher activity at lower pH value, and bactericidal effects with gram-positive bacteria than gram-negative bacteria in the presence of 0.1% chitOSan.
Journal ArticleDOI
Nanoparticles and microparticles for skin drug delivery
Tarl W. Prow,Jeffrey E. Grice,Lynlee L. Lin,Rokhaya Faye,Margaret K. Butler,Wolfgang Becker,Elisabeth M. T. Wurm,Corinne Yoong,Thomas Robertson,Thomas Robertson,H. Peter Soyer,Michael S. Roberts,Michael S. Roberts +12 more
TL;DR: Unpublished clinical data on nanoparticle penetration and previously published reports support the hypothesis that nanoparticles >10nm in diameter are unlikely to penetrate through the stratum corneum into viable human skin but will accumulate in the hair follicle openings, especially after massage.
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Solid lipid nanoparticles: Production, characterization and applications
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