Circadian rhythms, time-restricted feeding, and healthy aging.
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TLDR
Optimizing the timing of external cues with defined eating patterns can sustain a robust circadian clock, which may prevent disease and improve prognosis.About:
This article is published in Ageing Research Reviews.The article was published on 2017-10-01 and is currently open access. It has received 194 citations till now. The article focuses on the topics: Circadian clock & Chronobiology.read more
Citations
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Facing up to the global challenges of ageing.
TL;DR: Interventions, including changes to lifestyle and medical innovations, are needed to prevent disease and increase late-life health in humans.
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Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories
Sarah J. Mitchell,Michel Bernier,Julie A. Mattison,Miguel A. Aon,Tamzin A. Kaiser,R. Michael Anson,R. Michael Anson,Yuji Ikeno,Rozalyn M. Anderson,Donald K. Ingram,Rafael de Cabo +10 more
TL;DR: M mice ate quickly, imposing periods of extended daily fasting on themselves that produced significant improvements in morbidity and mortality compared with AL mice, which has major implications for human health and clinical applicability.
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Circadian rhythms and exercise — re-setting the clock in metabolic disease
TL;DR: This Review summarizes the current literature regarding the consequence of exercise at different times of the day and exercise can reset the molecular circadian clock, thereby effectively ameliorating the negative effects of disrupted sleep patterns.
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Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases.
TL;DR: Recent advancements on how to enhance the circadian clock through behavioral interventions, timing of drug administration, and pharmacological targeting of circadian clock components that are already providing new preventive and therapeutic strategies for several diseases, including metabolic syndrome and cancer are reviewed.
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New Insights Into the Circadian Rhythm and Its Related Diseases
TL;DR: This review summarized the synchronizers and the synchronization methods used in experimental research, and introduced CR monitoring and detection methods, and evaluated conventional CR databases and analyzed experiments that characterized the underlying causes of CR disorder.
References
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Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
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Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Francesca Damiola,Nguyet Le Minh,Nicolas Preitner,Benoît Kornmann,Fabienne Fleury-Olela,Ueli Schibler +5 more
TL;DR: It is shown that temporal feeding restriction under light-dark or dark-dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving thephase of cyclic gene expressionIn the SCN unaffected.
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A Functional Analysis of Circadian Pacemakers in Nocturnal Rodents. I. The Stability and Lability of Spontaneous Frequency
Serge Daan,Colin S. Pittendrigh +1 more
TL;DR: In this paper, a model of non-parametric entrainment of circadian pacemakers is tested for the case of nocturnal rodents using 1 or 2 light pulses per cycle, and the model makes use of the available data on freerunning period (τ) in constant darkness and on phase response curves (PRC) for short light pulses.
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The mammalian circadian timing system: organization and coordination of central and peripheral clocks.
TL;DR: This work discusses knowledge acquired during the past few years on the complex structure and function of the mammalian circadian timing system and some of the SCN output pathways serve as input pathways for peripheral tissues.
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Adverse metabolic and cardiovascular consequences of circadian misalignment
TL;DR: The findings demonstrate the adverse cardiometabolic implications of circadian misalignment, as occurs acutely with jet lag and chronically with shift work, on metabolic, autonomic, and endocrine predictors of obesity, diabetes, and cardiovascular risk.