Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study.
Tao Chen,Di Wu,Huilong Chen,Weiming Yan,Danlei Yang,Guang Chen,Ke Ma,Dong Xu,Haijing Yu,Hongwu Wang,Tao Wang,Wei Guo,Jia Chen,Chen Ding,Xiaoping Zhang,Jiaquan Huang,Meifang Han,Shusheng Li,Xiaoping Luo,Jianping Zhao,Qin Ning +20 more
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TLDR
Severe acute respiratory syndrome coronavirus 2 infection can cause both pulmonary and systemic inflammation, leading to multi-organ dysfunction in patients at high risk, including patients with cardiovascular comorbidity.Abstract:
Objective To delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died. Design Retrospective case series. Setting Tongji Hospital in Wuhan, China. Participants Among a cohort of 799 patients, 113 who died and 161 who recovered with a diagnosis of covid-19 were analysed. Data were collected until 28 February 2020. Main outcome measures Clinical characteristics and laboratory findings were obtained from electronic medical records with data collection forms. Results The median age of deceased patients (68 years) was significantly older than recovered patients (51 years). Male sex was more predominant in deceased patients (83; 73%) than in recovered patients (88; 55%). Chronic hypertension and other cardiovascular comorbidities were more frequent among deceased patients (54 (48%) and 16 (14%)) than recovered patients (39 (24%) and 7 (4%)). Dyspnoea, chest tightness, and disorder of consciousness were more common in deceased patients (70 (62%), 55 (49%), and 25 (22%)) than in recovered patients (50 (31%), 48 (30%), and 1 (1%)). The median time from disease onset to death in deceased patients was 16 (interquartile range 12.0-20.0) days. Leukocytosis was present in 56 (50%) patients who died and 6 (4%) who recovered, and lymphopenia was present in 103 (91%) and 76 (47%) respectively. Concentrations of alanine aminotransferase, aspartate aminotransferase, creatinine, creatine kinase, lactate dehydrogenase, cardiac troponin I, N-terminal pro-brain natriuretic peptide, and D-dimer were markedly higher in deceased patients than in recovered patients. Common complications observed more frequently in deceased patients included acute respiratory distress syndrome (113; 100%), type I respiratory failure (18/35; 51%), sepsis (113; 100%), acute cardiac injury (72/94; 77%), heart failure (41/83; 49%), alkalosis (14/35; 40%), hyperkalaemia (42; 37%), acute kidney injury (28; 25%), and hypoxic encephalopathy (23; 20%). Patients with cardiovascular comorbidity were more likely to develop cardiac complications. Regardless of history of cardiovascular disease, acute cardiac injury and heart failure were more common in deceased patients. Conclusion Severe acute respiratory syndrome coronavirus 2 infection can cause both pulmonary and systemic inflammation, leading to multi-organ dysfunction in patients at high risk. Acute respiratory distress syndrome and respiratory failure, sepsis, acute cardiac injury, and heart failure were the most common critical complications during exacerbation of covid-19.read more
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Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism
Mohamed Abu-Farha,Salman Al-Sabah,Maha M. Hammad,Prashantha Hebbar,Arshad Channanath,Sumi Elsa John,Ibrahim Taher,Abdulrahman Almaeen,Amany A. Ghazy,Anwar Mohammad,Jehad Abubaker,Hossein Arefanian,Fahd Al-Mulla,Thangavel Alphonse Thanaraj +13 more
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SARS-CoV-2 triggered neutrophil extracellular traps (NETs) mediate COVID-19 pathology
Flávio P. Veras,Marjorie Cornejo Pontelli,Camila S. Silva,Juliana E Toller-Kawahisa,Mikhael de Lima,Daniele C. Nascimento,Ayda Henriques Schneider,Diego B. Caetite,Roberta Ribeiro Costa Rosales,David F. Colón,Ronaldo Teixeira Martins,Italo A. Castro,Glaucia M. Almeida,Maria Isabel Lopes,Maira N. Benatti,Letícia Pastorelli Bonjorno,Marcela C Giannini,Rodrigo Luppino-Assad,Sérgio Mendonça de Almeida,Fernando Crivelenti Vilar,Rodrigo de Carvalho Santana,Valdes Roberto Bollela,Maria Lucia Refinetti Rodrigues Martins,Carlos Henrique Miranda,Marcos C. Borges,Antonio Pazin-Filho,Larissa D. Cunha,Dario S. Zamboni,Felipe Dal-Pizzol,Luiz O. Leiria,Li Siyuan,Sabrina Setembre Batah,Alexandre Todorovic Fabro,Thais Mauad,Marisa Dolhnikoff,Amaro Nunes Duarte-Neto,Paulo Hilário Nascimento Saldiva,Thiago M. Cunha,José C. Alves-Filho,Eurico Arruda,Paulo Louzada-Junior,Renê Donizeti Ribeiro de Oliveira,Fernando Q. Cunha +42 more
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Risk factors of the severity of COVID-19: A meta-analysis.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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