Journal ArticleDOI
Clinical epigenetics: seizing opportunities for translation.
María Berdasco,Manel Esteller +1 more
TLDR
Beyond helping to understand disease biology, clinical epigenetics is being incorporated into patient management in oncology, as well as being explored for clinical applicability for other human pathologies such as neurological and infectious diseases and immune system disorders.Abstract:
Biomarker discovery and validation are necessary for improving the prediction of clinical outcomes and patient monitoring. Despite considerable interest in biomarker discovery and development, improvements in the range and quality of biomarkers are still needed. The main challenge is how to integrate preclinical data to obtain a reliable biomarker that can be measured with acceptable costs in routine clinical practice. Epigenetic alterations are already being incorporated as valuable candidates in the biomarker field. Furthermore, their reversible nature offers a promising opportunity to ameliorate disease symptoms by using epigenetic-based therapy. Thus, beyond helping to understand disease biology, clinical epigenetics is being incorporated into patient management in oncology, as well as being explored for clinical applicability for other human pathologies such as neurological and infectious diseases and immune system disorders.read more
Citations
More filters
Integrative analysis of 111 reference human epigenomes
Anshul Kundaje,Wouter Meuleman,Jason Ernst,Angela Yen,Pouya Kheradpour,Zhizhuo Zhang,Jianrong Wang,Lucas D. Ward,Abhishek Sarkar,Gerald Quon,Matthew L. Eaton,Yi-Chieh Wu,Andreas R. Pfenning,Xinchen Wang,Melina Claussnitzer,Yaping Liu,Mukul S. Bansal,Soheil Feizi-Khankandi,Ah Ram Kim,Richard C Sallari,Nicholas A Sinnott-Armstrong,Laurie A. Boyer,Elizabeta Gjoneska,Li-Huei Tsai,Manolis Kellis +24 more
TL;DR: In this article, the authors describe the integrative analysis of 111 reference human epigenomes generated as part of the NIH Roadmap Epigenomics Consortium, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression.
Journal ArticleDOI
The Timeline of Epigenetic Drug Discovery: From Reality to Dreams
TL;DR: The timeline of epigenetic drug discovery and development is described, beginning with the early design based solely on phenotypic observations to the state-of-the-art rational epigenetics drug discovery using validated targets.
Journal ArticleDOI
Epigenetics in cancer therapy and nanomedicine.
TL;DR: The importance of the epigenetic alterations identified in human cancer, which have led to the appearance of biomarkers or epigenetic drugs in precision medicine, are summarized, and the transport and release systems of theigenetic drugs that have been developed to date are described.
Journal ArticleDOI
DNA Methylation Biomarkers in Aging and Age-Related Diseases.
TL;DR: This review will summarize key advances in epigenetic clocks and their potential application in precision health, and highlight the importance of prospective study designs to identify and confirm epigenetic biomarkers of disease.
Journal ArticleDOI
The Contribution of Epigenetics to Cancer Immunotherapy
TL;DR: A comprehensive up-to-date view of potential epigenetic biomarkers in immunotherapy is presented and their advantages over other indicators are discussed.
References
More filters
Journal ArticleDOI
Epigenetics of inflammatory arthritis.
Deepa Hammaker,Gary S. Firestein +1 more
TL;DR: The present article will review the recent advances in the epigenetic profile of inflammatory arthritis and discuss diagnostic biomarkers and potential therapeutic targets.
Journal Article
Reduced Rate of Repeated Prostate Biopsies Observed in ConfirmMDx Clinical Utility Field Study
Kirk J. Wojno,Frank J Costa,Robert J Cornell,Jeffrey D Small,Erik Pasin,Wim Van Criekinge,Joseph Bigley,Leander Van Neste +7 more
TL;DR: The data suggest that patients managed using the ConfirmMDx for Prostate Cancer negative results had a low rate of repeat prostate biopsies, and warrant a large, controlled, prospective study to further evaluate the clinical utility of the epigenetic test to lower the unnecessary repeat biopsy rate.
DNA Methylation in Embryo Development: Epigenetic Impact of ART
TL;DR: Studies showing the effect of culture media, ovarian stimulation or embryo transfer on the methylation pattern of embryos emphasize the need to face ART‐associated defects and search for strategies to mitigate adverse effects on the health of ART‐derived children.
Journal ArticleDOI
Histone Methylation Marks on Circulating Nucleosomes as Novel Blood-Based Biomarker in Colorectal Cancer
Ugur Gezer,Ebru Esin Yoruker,Metin Keskin,Cemil Burak Kulle,Yoganiranjana Dharuman,Stefan Holdenrieder +5 more
TL;DR: Findings of this preliminary study reveal the potential of blood-based detection of CRC by quantification of histone methylation marks and the additive effect of the marker combination.
Journal ArticleDOI
H3K27 demethylation at the proviral promoter sensitizes latent HIV to the effects of vorinostat in ex-vivo cultures of resting CD4+ T cells
Manoj K. Tripathy,Mary E Manson McManamy,Brandon D. Burch,Nancie M. Archin,David M. Margolis +4 more
TL;DR: GSK343, a potent and selective EZH2/EZH1 inhibitor, reduced trimethylation of histone 3 at lysine 27 (H3K27) of the HIV provirus in resting cells, providing a proof-of-concept for the testing of combination epigenetic approaches to disrupt latent HIV infection.