Journal ArticleDOI
Clinical epigenetics: seizing opportunities for translation.
María Berdasco,Manel Esteller +1 more
TLDR
Beyond helping to understand disease biology, clinical epigenetics is being incorporated into patient management in oncology, as well as being explored for clinical applicability for other human pathologies such as neurological and infectious diseases and immune system disorders.Abstract:
Biomarker discovery and validation are necessary for improving the prediction of clinical outcomes and patient monitoring. Despite considerable interest in biomarker discovery and development, improvements in the range and quality of biomarkers are still needed. The main challenge is how to integrate preclinical data to obtain a reliable biomarker that can be measured with acceptable costs in routine clinical practice. Epigenetic alterations are already being incorporated as valuable candidates in the biomarker field. Furthermore, their reversible nature offers a promising opportunity to ameliorate disease symptoms by using epigenetic-based therapy. Thus, beyond helping to understand disease biology, clinical epigenetics is being incorporated into patient management in oncology, as well as being explored for clinical applicability for other human pathologies such as neurological and infectious diseases and immune system disorders.read more
Citations
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Integrative analysis of 111 reference human epigenomes
Anshul Kundaje,Wouter Meuleman,Jason Ernst,Angela Yen,Pouya Kheradpour,Zhizhuo Zhang,Jianrong Wang,Lucas D. Ward,Abhishek Sarkar,Gerald Quon,Matthew L. Eaton,Yi-Chieh Wu,Andreas R. Pfenning,Xinchen Wang,Melina Claussnitzer,Yaping Liu,Mukul S. Bansal,Soheil Feizi-Khankandi,Ah Ram Kim,Richard C Sallari,Nicholas A Sinnott-Armstrong,Laurie A. Boyer,Elizabeta Gjoneska,Li-Huei Tsai,Manolis Kellis +24 more
TL;DR: In this article, the authors describe the integrative analysis of 111 reference human epigenomes generated as part of the NIH Roadmap Epigenomics Consortium, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression.
Journal ArticleDOI
The Timeline of Epigenetic Drug Discovery: From Reality to Dreams
TL;DR: The timeline of epigenetic drug discovery and development is described, beginning with the early design based solely on phenotypic observations to the state-of-the-art rational epigenetics drug discovery using validated targets.
Journal ArticleDOI
Epigenetics in cancer therapy and nanomedicine.
TL;DR: The importance of the epigenetic alterations identified in human cancer, which have led to the appearance of biomarkers or epigenetic drugs in precision medicine, are summarized, and the transport and release systems of theigenetic drugs that have been developed to date are described.
Journal ArticleDOI
DNA Methylation Biomarkers in Aging and Age-Related Diseases.
TL;DR: This review will summarize key advances in epigenetic clocks and their potential application in precision health, and highlight the importance of prospective study designs to identify and confirm epigenetic biomarkers of disease.
Journal ArticleDOI
The Contribution of Epigenetics to Cancer Immunotherapy
TL;DR: A comprehensive up-to-date view of potential epigenetic biomarkers in immunotherapy is presented and their advantages over other indicators are discussed.
References
More filters
Journal ArticleDOI
Valproic acid enhances neuronal differentiation of sympathoadrenal progenitor cells
Vladimir Vukicevic,Nan Qin,Maria Balyura,Graeme Eisenhofer,Ma-Li Wong,Julio Licinio,Stefan R. Bornstein,Monika Ehrhart-Bornstein +7 more
TL;DR: Similar to neural stem cells, VPA launches differentiation mechanisms in sympathoadrenal progenitor cells that result in increased generation of functional neurons that are relevant to the potential use of chromaffin progenitors in transplantation therapies of neurodegenerative diseases.
Journal ArticleDOI
Effects of Histone Deacetylase Inhibitors on Modulating H3K4 Methylation Marks - A Novel Cross-Talk Mechanism between Histone-Modifying Enzymes.
TL;DR: Evidence suggests that the crosstalk between histone deacetylation and histone H3K4 methylation is attributable to the ability of these HDAC inhibitors to repress the JARID1 family of hist one H3 lysine 4 demethylases (H3K 4DMs), including RBP2, PLU-1, SMCX, and LSD1, through the downregulation of Sp1 expression.
Journal ArticleDOI
Interleukin-2 receptor-α proximal promoter hypomethylation is associated with multiple sclerosis
Judith Field,Andrew Fox,Margaret A. Jordan,Alan G. Baxter,Tim Spelman,Melissa Gresle,Helmut Butzkueven,Trevor J. Kilpatrick,Justin P. Rubio,Justin P. Rubio +9 more
TL;DR: The data suggest that differential methylation of the IL2RA promoter in T cells could be an important pathogenic mechanism in MS, and DNA methylation differences specific to particular leukocyte subtypes in MS cases compared with controls are inferred by deconvolution of the array data.
Journal ArticleDOI
Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease.
Evelyn Ferri,Beatrice Arosio,Claudio D'Addario,Daniela Galimberti,Cristina Gussago,Mariangela Pucci,Martina Casati,Chiara Fenoglio,Carlo Abbate,Paolo Rossi,Elio Scarpini,Mauro Maccarrone,Daniela Mari +12 more
TL;DR: DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients is investigated to suggest an important and distinct involvement of Pin1 in these two types of dementia.
Journal ArticleDOI
DNA methylation at the 9p21 glaucoma susceptibility locus is associated with normal-tension glaucoma.
Kathryn P. Burdon,Kathryn P. Burdon,Mona S Awadalla,Paul Mitchell,Jie Jin Wang,Andrew White,Miriam C Keane,Emmanuelle Souzeau,Stuart L. Graham,Ivan Goldberg,Paul R. Healey,John Landers,Richard A. Mills,Stephen Best,Alex W. Hewitt,Alex W. Hewitt,Shiwani Sharma,Jamie E Craig +17 more
TL;DR: An association of methylation status in the CDKN2B promoter with NTG, particularly in females, suggests that the observed genetic association with the disease at this locus could be in part due to epigenetic mechanisms, and is likely to be independent of the association of nonsynonymous coding variation within the gene.