Journal ArticleDOI
Clinical epigenetics: seizing opportunities for translation.
María Berdasco,Manel Esteller +1 more
TLDR
Beyond helping to understand disease biology, clinical epigenetics is being incorporated into patient management in oncology, as well as being explored for clinical applicability for other human pathologies such as neurological and infectious diseases and immune system disorders.Abstract:
Biomarker discovery and validation are necessary for improving the prediction of clinical outcomes and patient monitoring. Despite considerable interest in biomarker discovery and development, improvements in the range and quality of biomarkers are still needed. The main challenge is how to integrate preclinical data to obtain a reliable biomarker that can be measured with acceptable costs in routine clinical practice. Epigenetic alterations are already being incorporated as valuable candidates in the biomarker field. Furthermore, their reversible nature offers a promising opportunity to ameliorate disease symptoms by using epigenetic-based therapy. Thus, beyond helping to understand disease biology, clinical epigenetics is being incorporated into patient management in oncology, as well as being explored for clinical applicability for other human pathologies such as neurological and infectious diseases and immune system disorders.read more
Citations
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Integrative analysis of 111 reference human epigenomes
Anshul Kundaje,Wouter Meuleman,Jason Ernst,Angela Yen,Pouya Kheradpour,Zhizhuo Zhang,Jianrong Wang,Lucas D. Ward,Abhishek Sarkar,Gerald Quon,Matthew L. Eaton,Yi-Chieh Wu,Andreas R. Pfenning,Xinchen Wang,Melina Claussnitzer,Yaping Liu,Mukul S. Bansal,Soheil Feizi-Khankandi,Ah Ram Kim,Richard C Sallari,Nicholas A Sinnott-Armstrong,Laurie A. Boyer,Elizabeta Gjoneska,Li-Huei Tsai,Manolis Kellis +24 more
TL;DR: In this article, the authors describe the integrative analysis of 111 reference human epigenomes generated as part of the NIH Roadmap Epigenomics Consortium, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression.
Journal ArticleDOI
The Timeline of Epigenetic Drug Discovery: From Reality to Dreams
TL;DR: The timeline of epigenetic drug discovery and development is described, beginning with the early design based solely on phenotypic observations to the state-of-the-art rational epigenetics drug discovery using validated targets.
Journal ArticleDOI
Epigenetics in cancer therapy and nanomedicine.
TL;DR: The importance of the epigenetic alterations identified in human cancer, which have led to the appearance of biomarkers or epigenetic drugs in precision medicine, are summarized, and the transport and release systems of theigenetic drugs that have been developed to date are described.
Journal ArticleDOI
DNA Methylation Biomarkers in Aging and Age-Related Diseases.
TL;DR: This review will summarize key advances in epigenetic clocks and their potential application in precision health, and highlight the importance of prospective study designs to identify and confirm epigenetic biomarkers of disease.
Journal ArticleDOI
The Contribution of Epigenetics to Cancer Immunotherapy
TL;DR: A comprehensive up-to-date view of potential epigenetic biomarkers in immunotherapy is presented and their advantages over other indicators are discussed.
References
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An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins
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