Clinical presentation and outcomes for adult ependymoma patients.
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TLDR
The Adult Ependymoma Outcomes survey uses self‐reported experience to evaluate how this tumor affects patient groups throughout the illness trajectory.Abstract:
BACKGROUND
Outcomes projects can be a catalyst for determining disease- and treatment-related consequences for patients with rare tumors. The Adult Ependymoma Outcomes (AEO) survey uses self-reported experience to evaluate how this tumor affects patient groups throughout the illness trajectory.
METHODS
Patients completed the AEO survey via a Web-based portal. The survey included questions on treatment, tumor recurrence, and current health status; the MD Anderson Symptom Inventory Brain Tumor and Spine Tumor modules; and the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36).
RESULTS
The sample included 264 participants (57% female) with a median age of 46 years (range, 18-77 years). Radiation treatment was commonly used for patients who had brain involvement (χ2(1) = 20.7; P < .001), underwent a partial resection (43%; χ2(3) = 15.4; P < .001), or had a grade 3 tumor (41%; χ2(2) = 18.8; P < .001). Recurrence occurred in a small group (29%), with grade 1 tumor patients 2.6 times more likely and grade 3 tumor patients 2.5 times more likely to experience recurrence than those with grade 2 tumors. Spine tumor patients had a higher symptom burden (mean, 2.8; scale, 0-10) than brain tumor patients (t(247) = −4.0), and they reported more moderate to severe symptoms (rating ≥ 5; 29%) than their counterparts (18%). Within the physical health portion of the SF-36, spine tumor patients reported worse health with respect to bodily pain (t(249) = 6.8; P < .001), physical functioning (t(252) = 4.1; P < .001), and vitality (t(202.2) = 3.0; P < .003).
CONCLUSIONS
These results demonstrate the feasibility of implementing outcomes projects that report on the clinical and demographic characteristics of a rare patient population, and they underscore the importance of outcomes data in understanding disease-related issues. Cancer 2016. © 2016 American Cancer Society.read more
Citations
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EANO guidelines for the diagnosis and treatment of ependymal tumors.
Roberta Rudà,Guido Reifenberger,Didier Frappaz,Stefan M. Pfister,Anne Laprie,Thomas Santarius,Patrick Roth,Joerg C. Tonn,Riccardo Soffietti,Michael Weller,Elizabeth Cohen-Jonathan Moyal +10 more
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Recent Advances in the Classification and Treatment of Ependymomas.
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Review of ependymomas: assessment of consensus in pathological diagnosis and correlations with genetic profiles and outcome
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Recursive partitioning analysis for disease progression in adult intracranial ependymoma patients
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Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups
Kristian W. Pajtler,Kristian W. Pajtler,Hendrik Witt,Martin Sill,David T.W. Jones,Volker Hovestadt,Fabian Kratochwil,Khalida Wani,Ruth G. Tatevossian,Chandanamali Punchihewa,Pascal Johann,Jüri Reimand,Hans-Jörg Warnatz,Marina Ryzhova,Steve Mack,Vijay Ramaswamy,David Capper,David Capper,Leonille Schweizer,Leonille Schweizer,Laura Sieber,Andrea Wittmann,Zhiqin Huang,Peter van Sluis,Richard Volckmann,Jan Koster,Rogier Versteeg,Daniel W. Fults,Helen Toledano,Smadar Avigad,Lindsey M. Hoffman,Andrew M. Donson,Nicholas K. Foreman,Ekkehard Hewer,Karel Zitterbart,Mark R. Gilbert,Terri S. Armstrong,Terri S. Armstrong,Nalin Gupta,Jeffrey C. Allen,Matthias A. Karajannis,David Zagzag,Martin Hasselblatt,Andreas E. Kulozik,Olaf Witt,V. Peter Collins,Katja von Hoff,Stefan Rutkowski,Torsten Pietsch,Gary D. Bader,Marie-Laure Yaspo,Andreas von Deimling,Andreas von Deimling,Peter Lichter,Michael D. Taylor,Richard J. Gilbertson,David W. Ellison,Kenneth Aldape,Andrey Korshunov,Andrey Korshunov,Marcel Kool,Stefan M. Pfister +61 more
TL;DR: The molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.
Journal ArticleDOI
C11orf95 – RELA fusions drive oncogenic NF-κB signalling in ependymoma
Matthew Parker,Kumarasamypet M. Mohankumar,Chandanamali Punchihewa,Ricardo Weinlich,James Dalton,Yongjin Li,Ryan P. Lee,Ruth G. Tatevossian,Timothy N. Phoenix,Radhika Thiruvenkatam,Elsie White,Bo Tang,Wilda Orisme,Kirti Gupta,Michael Rusch,Xiang Chen,Yuxin Li,Panduka Nagahawhatte,Erin Hedlund,David Finkelstein,Gang Wu,Sheila A. Shurtleff,John Easton,Kristy Boggs,Donald Yergeau,Bhavin Vadodaria,Heather L. Mulder,Jared Becksford,Pankaj Gupta,Robert Huether,Jing Ma,Guangchun Song,Amar Gajjar,Thomas E. Merchant,Frederick A. Boop,Amy A Smith,Li Ding,Charles Lu,Kerri Ochoa,David Zhao,Robert S. Fulton,Lucinda Fulton,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Douglas R. Green,Jinghui Zhang,David W. Ellison,Richard J. Gilbertson +48 more
TL;DR: The data identify a highly recurrent genetic alteration of RELA in human cancer, and the C11orf95–RELA fusion protein as a potential therapeutic target in supratentorial ependymoma.
Journal ArticleDOI
Validation of the M.D. Anderson Symptom Inventory Brain Tumor Module (MDASI-BT).
Terri Armstrong,Terri Armstrong,Tito R. Mendoza,I. Gring,C. Coco,Marlene Z. Cohen,Marlene Z. Cohen,L. Eriksen,L. Eriksen,Ming Ann Hsu,Mark R. Gilbert,Charles S. Cleeland +11 more
TL;DR: The 22 item MDASI-BT demonstrated validity and reliability in patients with PBT and can be used to identify symptom occurrence throughout the disease trajectory and to evaluate interventions designed for symptom management.
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