Cognitive Disorders and Dementia in CKD: The Neglected Kidney-Brain Axis
Jean-Marc Bugnicourt,Olivier Godefroy,Jean-Marc Chillon,Jean-Marc Chillon,Gabriel Choukroun,Ziad A. Massy,Ziad A. Massy +6 more
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TLDR
The prevalence and characteristics of cognitive disorders and dementia in patients with CKD, brain imaging findings, and traditional and nontraditional risk factors are discussed.Abstract:
Epidemiologic data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including direct neuronal injury by uremic toxins, could also be involved, especially in the absence of obvious cerebrovascular disease. We discuss the prevalence and characteristics of cognitive disorders and dementia in patients with CKD, brain imaging findings, and traditional and nontraditional risk factors. Understanding the pathophysiologic interactions between renal impairment and brain function is important in order to minimize the risk for future cognitive impairment.read more
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Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies
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TL;DR: The latest release of the T3DB has been substantially upgraded to include many more compounds, targets and gene expression datasets, and now includes extensive data on ‘normal’ toxic compound concentrations in human biofluids as well as detailed chemical taxonomies, informative chemical ontologies and a large number of referential NMR, MS/MS and GC-MS spectra.
References
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Journal ArticleDOI
Silent Brain Infarction and Rapid Decline of Kidney Function in Patients With CKD: A Prospective Cohort Study
Mayumi Kobayashi,Mayumi Kobayashi,Nobuhito Hirawa,Satoshi Morita,Keisuke Yatsu,Yusuke Kobayashi,Yuichiro Yamamoto,Yuichiro Yamamoto,Sanae Saka,Sanae Saka,Yoshiyuki Toya,Gen Yasuda,Satoshi Umemura +12 more
TL;DR: It is shown that SBI was an important independent prognostic factor for the progression of kidney disease in patients with CKD and that patients with SBI should be considered a high-risk population for decreased kidney function.
Journal ArticleDOI
Cerebral computed tomography in uremic and hemodialyzed patients.
TL;DR: Cerebral CT revealed areas of low density related to past episodes of cerebral ischemia and some small calcifications in the brain parenchyma that seems to correlate with the duration of uremia.
Journal Article
[Renal Epidemiology and Information Network: 2006 annual report].
TL;DR: In 2006, 6,509 patients with end-stage renal disease living in 16 regions covering 48(M) inhabitants (79% of the French population), started renal replacement therapy (dialysis or preemptive graft), with significant differences in sex and age-adjusted incidence across regions.
Cerebral atrophy in end-stage uremia.
TL;DR: Cerebral atrophy is present in end-stage uremia and is most marked during the ages of cerebral development, but is also present in adults, and the degree of atrophy correlates best with the age of onset of end- Stage Uremia.
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Pathophysiological mechanisms and consequences of cardiovascular calcifications: role of uremic toxicity.
Jean-Marc Chillon,Anaïs Mozar,Isabelle Six,Julien Maizel,Jean-Marc Bugnicourt,Said Kamel,Michel Slama,Michel Brazier,Ziad A. Massy +8 more
TL;DR: In this article, the role of uremic toxicity in the pathogenesis of cardiovascular calcification was investigated and shown to have independent effects on vascular walls, at least in the early stages of chronic kidney disease.