Cognitive Disorders and Dementia in CKD: The Neglected Kidney-Brain Axis
Jean-Marc Bugnicourt,Olivier Godefroy,Jean-Marc Chillon,Jean-Marc Chillon,Gabriel Choukroun,Ziad A. Massy,Ziad A. Massy +6 more
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TLDR
The prevalence and characteristics of cognitive disorders and dementia in patients with CKD, brain imaging findings, and traditional and nontraditional risk factors are discussed.Abstract:
Epidemiologic data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including direct neuronal injury by uremic toxins, could also be involved, especially in the absence of obvious cerebrovascular disease. We discuss the prevalence and characteristics of cognitive disorders and dementia in patients with CKD, brain imaging findings, and traditional and nontraditional risk factors. Understanding the pathophysiologic interactions between renal impairment and brain function is important in order to minimize the risk for future cognitive impairment.read more
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Journal ArticleDOI
Impact of unilateral ureteral obstruction on cognition and neurodegeneration.
Yuen Shan Ho,Chi Fai Lau,Krit Lee,Jia Yan Tan,Joyce Man-Fong Lee,Susan Yung,Raymond Chuen-Chung Chang +6 more
TL;DR: In this paper, the authors used unilateral ureteral obstruction (UUO) in mice as an animal model to study the cognitive changes and related pathology under prolonged renal impairment in CKD patients.
Dissertation
Comparison of Cognitive Functions between Diabetic andNon Diabetic Chronic Kidney Disease Patients (Stage 5D ) and Its Correlation with Serum Uric Acid, Hemoglobin andSerum Ferritin Levels
TL;DR: Blood samples were collected to estimate serum uric acid, haemoglobin and serum ferritin levels and cognitive functions were assessed using NIMHANS neuropsychology battery 2004.
Journal ArticleDOI
Association of Cognitive Function Screening Results with Adherence and Performance in a Pedometer-Based Intervention
Anoop Sheshadri,Piyawan Kittiskulnam,Cynthia Delgado,Cynthia Delgado,Rebecca L. Sudore,Jennifer C. Lai,Kirsten L. Johansen +6 more
TL;DR: In this paper, a randomized, controlled trial of a pedometer-based walking intervention with weekly activity goals led to increased walking among dialysis patients, and the association of levels of impairment on the Telephone Interview of Cognitive Status (TICS) with adherence, achieving weekly goals, and increasing steps, physical performance (SPPB) through multivariable linear mixed-model and logistic regression analyses adjusted for age, sex, BMI, dialysis modality, baseline steps, baseline SPPB, and stroke status.
Journal ArticleDOI
Biomarkers involved in the pathogenesis of cerebral small-vessel disease
TL;DR: This work aimed to systematically review and summarize studies on the progress of biomarkers related to the pathogenesis of CSVD, which is mainly the relationship between these indicators and neuroimaging markers ofCSVD.
References
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