Cognitive Disorders and Dementia in CKD: The Neglected Kidney-Brain Axis
Jean-Marc Bugnicourt,Olivier Godefroy,Jean-Marc Chillon,Jean-Marc Chillon,Gabriel Choukroun,Ziad A. Massy,Ziad A. Massy +6 more
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TLDR
The prevalence and characteristics of cognitive disorders and dementia in patients with CKD, brain imaging findings, and traditional and nontraditional risk factors are discussed.Abstract:
Epidemiologic data suggest that individuals at all stages of CKD have a higher risk of developing cognitive disorders and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including direct neuronal injury by uremic toxins, could also be involved, especially in the absence of obvious cerebrovascular disease. We discuss the prevalence and characteristics of cognitive disorders and dementia in patients with CKD, brain imaging findings, and traditional and nontraditional risk factors. Understanding the pathophysiologic interactions between renal impairment and brain function is important in order to minimize the risk for future cognitive impairment.read more
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Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies
Kay Deckers,Martin P.J. van Boxtel,Olga J. G. Schiepers,Marjolein E. de Vugt,Juan Luis Muñoz Sánchez,Kaarin J. Anstey,Carol Brayne,Jean-François Dartigues,Knut Engedal,Miia Kivipelto,Karen Ritchie,John M. Starr,Kristine Yaffe,Kate Irving,Frans R.J. Verhey,Sebastian Köhler +15 more
TL;DR: The goal of this paper is to identify the major modifiable risk factors for dementia as a first step in developing an effective preventive strategy and promoting healthy late life cognitive functioning.
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The prevention of dementia with antihypertensive treatment. New evidence from the systolic hypertension in europe (Syst-Eur) study☆
TL;DR: The extended follow-up of Syst-Eur patients reinforces the evidence that blood pressure-lowering therapy initiated with a long-acting dihydropyridine protects against dementia in older patients with systolic hypertension.
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Stroke and cerebrovascular diseases in patients with chronic kidney disease
TL;DR: The pathophysiological interactions between the brain and kidney should be the subject of intensive study in view of the strong two-way association between stroke and kidney disease.
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T3DB: the toxic exposome database
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TL;DR: The latest release of the T3DB has been substantially upgraded to include many more compounds, targets and gene expression datasets, and now includes extensive data on ‘normal’ toxic compound concentrations in human biofluids as well as detailed chemical taxonomies, informative chemical ontologies and a large number of referential NMR, MS/MS and GC-MS spectra.
References
More filters
Journal ArticleDOI
Cognitive impairment in chronic kidney disease.
TL;DR: Assessment of the prevalence of cognitive impairment in persons with chronic kidney disease and its relation to the severity of CKD finds no clear relationship between CKD severity and cognitive impairment.
Journal ArticleDOI
Chronic Kidney Disease and Cognitive Impairment in the Elderly: The Health, Aging, and Body Composition Study
Manjula Kurella,Glenn M. Chertow,Linda F. Fried,Steven R. Cummings,Steven R. Cummings,Tamara B. Harris,Eleanor M. Simonsick,Suzanne Satterfield,Hilsa N. Ayonayon,Kristine Yaffe +9 more
TL;DR: CKD is associated with an increased risk for cognitive impairment in the elderly that cannot be fully explained by other well-established risk factors and efforts to interrupt this decline are warranted.
Journal ArticleDOI
Association of MRI Markers of Vascular Brain Injury With Incident Stroke, Mild Cognitive Impairment, Dementia, and Mortality The Framingham Offspring Study
Stéphanie Debette,Alexa S. Beiser,Alexa S. Beiser,Charles DeCarli,Rhoda Au,Rhoda Au,Jayandra J. Himali,Jayandra J. Himali,Margaret Kelly-Hayes,Margaret Kelly-Hayes,Jose R. Romero,Jose R. Romero,Carlos S. Kase,Carlos S. Kase,Philip A. Wolf,Philip A. Wolf,Sudha Seshadri,Sudha Seshadri +17 more
TL;DR: In a large community-based sample of middle-aged adults, BI predicted an increased risk of stroke and dementia independent of vascular risk factors and interim vascular events.
Journal ArticleDOI
Low glomerular filtration rate and risk of stroke: meta-analysis.
TL;DR: A baseline eGFR <60 ml/min/1.73 m2 was independently related to incident stroke across a variety of participants and study designs, and Prompt and appropriate implementation of established strategies for reduction of vascular risk in people with know renal insufficiency may prevent future strokes.
Journal ArticleDOI
US Renal Data System 2010 Annual Data Report
Allan J. Collins,Robert N. Foley,Charles A. Herzog,Blanche M. Chavers,David T. Gilbertson,Areef Ishani,Bertram L. Kasiske,Jiannong Liu,Lih Wen Mau,Marshall McBean,Anne M. Murray,Wendy L. St. Peter,Haifeng Guo,Sally K. Gustafson,Qi Li,Shuling Li,Suying Li,Yi Peng,Yang Qiu,Tricia Roberts,Melissa Skeans,Jon J. Snyder,Craig A. Solid,Changchun Wang,Eric D. Weinhandl,David Zaun,Cheryl Arko,Shu Cheng Chen,Frederick Dalleska,Frank Daniels,Stephan Dunning,James P. Ebben,Eric Frazier,Christopher Hanzlik,Roger Johnson,Daniel Sheets,Xinyue Wang,Beth Forrest,Edward Constantini,Susan Everson,Paul W. Eggers,Lawrence Y. Agodoa +41 more
TL;DR: Allan J. Collins, MD, Robert N. Foley, MB, Charles Herzog,MD, Blanche Chavers, MDs, David Gilbertson, PhD, Areef Ishani, Md, MS, Bertram Kasiske, MD and Jiannong Liu, PhD.