Commitment to a cellular transition precedes genome-wide transcriptional change
TLDR
It is found that genes within the G1/S regulon have a well-defined distribution of transcriptional activation times, which results in a logical OR function for gene expression and partially explains activation timing.About:
This article is published in Molecular Cell.The article was published on 2011-08-19 and is currently open access. It has received 84 citations till now. The article focuses on the topics: E2F Transcription Factors & Regulon.read more
Citations
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Journal ArticleDOI
Control of cell cycle transcription during G1 and S phases
TL;DR: The complex molecular mechanisms that control the temporal order of transcriptional activation and inactivation, determine distinct functional subgroups of genes and link cell cycle-dependent transcription to DNA replication stress in yeast and mammals are revealed.
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Cell Size Control in Yeast
TL;DR: Examination of size-sensing models based on spatial gradients and molecular titration, coupled with elucidation of the pathways responsible for nutrient-modulated target size, may reveal the fundamental principles of eukaryotic cell size control.
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Regulating DNA Replication in Eukarya
TL;DR: Work from several organisms has revealed a conserved strategy whereby inactive replication complexes are assembled onto DNA during periods of low CDK and high APC activity but are competent to execute genome duplication only when these activities are reversed.
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Distinct Interactions Select and Maintain a Specific Cell Fate
TL;DR: A quantitative single-cell analysis of commitment dynamics during the mating-mitosis switch in budding yeast shows that specification and maintenance of a cellular state are performed by distinct interactions, which are likely a consequence of disparate reaction rates and may be a general feature of the interlinked regulatory networks responsible for selecting cell fates.
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Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae
Lei Shi,Benjamin P. Tu +1 more
TL;DR: It is shown that a central metabolite of glucose catabolism, acetyl-CoA, induces CLN3 transcription by promoting the acetylation of histones present in its regulatory region.
References
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The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle
TL;DR: A reliable transcriptional network is provided at the G1-to-S transition in the budding yeast cell cycle by integrating heterogeneous genome-wide datasets into a single probabilistic model based on Bayesian statistics.
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A Skp2 autoinduction loop and restriction point control.
TL;DR: It is proposed that the essential role for Skp2-dependent degradation of p27 is in the formation of an autoinduction loop that selectively controls the transition to mitogen-independence, and that Skp 2-dependent proteolysis may be dispensable when pocket proteins are constitutively inactivated.
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Timing of Events in Mitosis
TL;DR: The results suggest that during early mitosis (from prophase to metaphase) the timing of biochemical events and morphological events is at least partly controlled by the responses of the substrates themselves to a common set of signals.
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Early cell cycle box-mediated transcription of CLN3 and SWI4 contributes to the proper timing of the G(1)-to-S transition in budding yeast.
TL;DR: Observations support the view that the coordinated rise of Cln3 and Swi4 levels mediated by ECB-dependent transcription controls the timing of the G1-to-S phase transition.
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Tuning the Activation Threshold of a Kinase Network by Nested Feedback Loops
TL;DR: It is demonstrated that intracellular signaling nodes can tune a signaling network’s response threshold away from the basal median effective concentration established by ligand-receptor interactions, which helps to explain the layered complexity seen in signal transduction networks.