Commitment to a cellular transition precedes genome-wide transcriptional change
TLDR
It is found that genes within the G1/S regulon have a well-defined distribution of transcriptional activation times, which results in a logical OR function for gene expression and partially explains activation timing.About:
This article is published in Molecular Cell.The article was published on 2011-08-19 and is currently open access. It has received 84 citations till now. The article focuses on the topics: E2F Transcription Factors & Regulon.read more
Citations
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Journal ArticleDOI
Tension and robustness in multitasking cellular networks.
TL;DR: This work developed a generic computational framework to examine the source and consequences of tension between pairs of dynamics exhibited by the well-studied RB-E2F switch regulating cell cycle entry and found that tension arose from task-dependent shifts in parameters associated with network modules.
Journal ArticleDOI
Simple rules for complex processes: new lessons from the budding yeast cell cycle.
TL;DR: Two papers in this issue of Molecular Cell present some satisfyingly simple ideas for the organization of the complex network that controls cell cycle progression and cell fate specification in budding yeast.
Posted ContentDOI
Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size
Matthew P. Swaffer,Devon Chandler-Brown,Jacob Kim,Maurice Langhinrichs,Georgi K. Marinov,William J. Greenleaf,Anshul Kundaje,Kurt M. Schmoller,Jan M. Skotheim +8 more
TL;DR: In this article, a transcriptional control uncouples Whi5 synthesis from cell size and, screening for similar genes, identify histones as the major class of sub-scaling transcripts besides WHI5.
Journal ArticleDOI
Whi7 is an unstable cell-cycle repressor of the Start transcriptional program
TL;DR: The authors show that the sequence related protein Whi7 associates to G1/S gene promoters in late G1 and collaborates with Whi5 in Start repression, bringing to light that yeast cells, as occurs in mammalian cells, rely on the combined action of multiple transcriptional repressors to block Start transition.
Journal ArticleDOI
The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle.
TL;DR: It is shown that the TF network can generate and transmit a “pulse” of transcription independently of CDK oscillations, suggesting a unique oscillatory mechanism in which global phase-specific transcription emerges from a pulse-generating network that fires once-and-only-once at the start of the cycle.
References
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Comprehensive Identification of Cell Cycle–regulated Genes of the Yeast Saccharomyces cerevisiae by Microarray Hybridization
Paul T. Spellman,Gavin Sherlock,Gavin Sherlock,Michael Q. Zhang,Vishwanath R. Iyer,Kirk R. Anders,Michael B. Eisen,Patrick O. Brown,Patrick O. Brown,David Botstein,Bruce Futcher +10 more
TL;DR: A comprehensive catalog of yeast genes whose transcript levels vary periodically within the cell cycle is created, and it is found that the mRNA levels of more than half of these 800 genes respond to one or both of these cyclins.
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Global analysis of protein expression in yeast
Sina Ghaemmaghami,Won-Ki Huh,Kiowa Bower,Russell W. Howson,Archana Belle,Noah Dephoure,Erin K. O'Shea,Jonathan S. Weissman +7 more
TL;DR: A Saccharomyces cerevisiae fusion library is created where each open reading frame is tagged with a high-affinity epitope and expressed from its natural chromosomal location, and it is found that about 80% of the proteome is expressed during normal growth conditions.
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Network motifs in the transcriptional regulation network of Escherichia coli
TL;DR: This work applied new algorithms for systematically detecting network motifs to one of the best-characterized regulation networks, that of direct transcriptional interactions in Escherichia coli, and finds that much of the network is composed of repeated appearances of three highly significant motifs.
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Checkpoints: controls that ensure the order of cell cycle events
Leland H. Hartwell,Ted Weinert +1 more
TL;DR: It appears that some checkpoints are eliminated during the early embryonic development of some organisms; this fact may pose special problems for the fidelity of embryonic cell division.
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A Genome-Wide Transcriptional Analysis of the Mitotic Cell Cycle
Raymond J. Cho,Michael J. Campbell,Elizabeth A. Winzeler,Lars M. Steinmetz,Andrew R. Conway,Lisa Wodicka,Tyra G. Wolfsberg,Andrei Gabrielian,David Landsman,David J. Lockhart,Ronald W. Davis +10 more
TL;DR: The genome-wide characterization of mRNA transcript levels during the cell cycle of the budding yeast S. cerevisiae indicates a mechanism for local chromosomal organization in global mRNA regulation and links a range of human genes to cell cycle period-specific biological functions.