Commitment to a cellular transition precedes genome-wide transcriptional change
TLDR
It is found that genes within the G1/S regulon have a well-defined distribution of transcriptional activation times, which results in a logical OR function for gene expression and partially explains activation timing.About:
This article is published in Molecular Cell.The article was published on 2011-08-19 and is currently open access. It has received 84 citations till now. The article focuses on the topics: E2F Transcription Factors & Regulon.read more
Citations
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Control of cell cycle transcription during G1 and S phases
TL;DR: The complex molecular mechanisms that control the temporal order of transcriptional activation and inactivation, determine distinct functional subgroups of genes and link cell cycle-dependent transcription to DNA replication stress in yeast and mammals are revealed.
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Cell Size Control in Yeast
TL;DR: Examination of size-sensing models based on spatial gradients and molecular titration, coupled with elucidation of the pathways responsible for nutrient-modulated target size, may reveal the fundamental principles of eukaryotic cell size control.
Journal ArticleDOI
Regulating DNA Replication in Eukarya
TL;DR: Work from several organisms has revealed a conserved strategy whereby inactive replication complexes are assembled onto DNA during periods of low CDK and high APC activity but are competent to execute genome duplication only when these activities are reversed.
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Distinct Interactions Select and Maintain a Specific Cell Fate
TL;DR: A quantitative single-cell analysis of commitment dynamics during the mating-mitosis switch in budding yeast shows that specification and maintenance of a cellular state are performed by distinct interactions, which are likely a consequence of disparate reaction rates and may be a general feature of the interlinked regulatory networks responsible for selecting cell fates.
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Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae
Lei Shi,Benjamin P. Tu +1 more
TL;DR: It is shown that a central metabolite of glucose catabolism, acetyl-CoA, induces CLN3 transcription by promoting the acetylation of histones present in its regulatory region.
References
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Journal ArticleDOI
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
Heiko Muller,Adrian P. Bracken,Richard Vernell,M. Cristina Moroni,Fred Christians,Emanuela Grassilli,Elena Prosperini,Elena Vigo,Jonathan D. Oliner,Kristian Helin +9 more
TL;DR: It is shown that the E2Fs control the expression of several genes that are involved in cell proliferation and apoptosis, differentiation, and development and provide possible genetic explanations to the variety of phenotypes observed as a consequence of a deregulated pRB/E2F pathway.
Book
The Cell Cycle: Principles of Control
David O. Morgan,David Morgan +1 more
TL;DR: The Cell Cycle in Cancer and Model Organisms in Cell-Cycle Analysis: Preparing for Chromosome Segregation and the Completion of Mitosis is presented.
Journal ArticleDOI
A positive-feedback-based bistable ‘memory module’ that governs a cell fate decision
Wen Xiong,James E. Ferrell +1 more
TL;DR: The results explain how a group of intrinsically reversible signal transducers can generate an irreversible response at a systems level, and show how a cell fate can be maintained by a self-sustaining pattern of protein kinase activation.
Journal ArticleDOI
Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast
Matthew J. Brauer,Curtis Huttenhower,Edoardo M. Airoldi,Rachel Rosenstein,Rachel Rosenstein,John C. Matese,David Gresham,Viktor Marius Boer,Olga G. Troyanskaya,David Botstein +9 more
TL;DR: Using an aggregate of gene expression values, an "instantaneous growth rate" is predicted, useful in interpreting the system-level connections among growth rate, metabolism, stress, and the cell cycle.
Journal ArticleDOI
E2F target genes: unraveling the biology.
TL;DR: This work has identified several hundred genes involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis, differentiation and development in retinoblastoma patients.