Journal ArticleDOI
Competing on the edge
TLDR
A new study focusing on glutamate-mediated transmission in the cerebellum describes the specific role of neuronal transporters in modulating the access of glutamate to extrasynaptic metabotropic glutamate receptors, and reveals important consequences of Extrasynaptic signaling on synaptic plasticity.About:
This article is published in Trends in Neurosciences.The article was published on 2002-06-01. It has received 339 citations till now. The article focuses on the topics: Metabotropic glutamate receptor & Synaptic cleft.read more
Citations
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Entrepreneurial orientation and small business performance : A Configurational Approach
TL;DR: In this paper, the authors investigate the EO of small businesses and find that a main-effects-only analysis provides an incomplete picture of performance, and they find that when combined with EO (a three-way interaction model) the configurational approach explains variance in performance over and above a contingency model (two-way interactions) and a main effects-only model.
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Institutional Transitions and Strategic Choices
TL;DR: In this article, a two-phase model of institutional transitions is developed, focusing on the longitudinal process to move from a relationship-based, personalized transaction structure calling for a network-centered strategy to a rule-based impersonal exchange regime suggesting a market-centric strategy.
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Supply networks and complex adaptive systems: Control versus emergence
TL;DR: In this article, the authors argue that many supply networks emerge rather than result from purposeful design by a singular entity and that the emergent patterns in a supply network can much better be managed through positive feedback, which allows for autonomous action.
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Strategic entrepreneurship: entrepreneurial strategies for wealth creation
TL;DR: In this paper, the authors explore strategic entrepreneurship in several important organizational domains to include external networks and alliances, resources and organizational learning, innovation and internationalization, and integrate, extend and test theory and research from entrepreneurship and strategic management in new ways such as creative destruction (discontinuities), resource-based view, organizational learning and transaction costs.
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Exploratory Learning, Innovative Capacity, and Managerial Oversight
TL;DR: In a study of 56 new business development projects, given high levels of exploration, organizational learning was more effective when the projects operated with autonomy with respect to goals and supervision.
References
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Journal ArticleDOI
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
TL;DR: In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of post Synaptic action potentials and unitary excitatory postsynaptic potentials was found to induce changes in EPSPs.
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Gamma (40-100 Hz) oscillation in the hippocampus of the behaving rat
TL;DR: It is suggested that gamma oscillation emerges from an interaction between intrinsic oscillatory properties of interneurons and the network properties of the dentate gyrus and that Gamma oscillation in the CA3-CA1 circuitry is suppressed by either the hilar region or the entorhinal cortex.
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The metabotropic glutamate receptor (mGluRlα) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction
Agnès Baude,Zoltan Nusser,J. David B. Roberts,Eileen R. Mulvihill,R.A. Jeffrey Mcllhinney,Peter Somogyi +5 more
TL;DR: Electron microscopic immunometal detection of mGluR1 alpha showed a preferential localization at the periphery of the extensive postsynaptic densities of type 1 synapses in both the cerebellum and the hippocampus.
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Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice.
Atsu Aiba,Masanobu Kano,Chong Chen,Chong Chen,Mark E. Stanton,Gregory D. Fox,Karl Herrup,Theresa A. Zwingman,Susumu Tonegawa,Susumu Tonegawa +9 more
TL;DR: It is concluded that mGLUR1 is required for the induction of LTD and that the ataxic behavior and impaired eyeblink conditioning of the mGluR1 mutant mice are primarily due to deficient LTD.
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Coherence of gamma-band EEG activity as a basis for associative learning.
TL;DR: It is found that another measure, gamma-band coherence, increases between regions of the brain that receive the two classes of stimuli involved in an associative-learning procedure in humans, which could fulfil the criteria required for the formation of hebbian cell assemblies.