Journal ArticleDOI
Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system.
David von Schack,Elisabeth Casademunt,Rüdiger Schweigreiter,Michael Meyer,Miriam Bibel,Georg Dechant +5 more
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TLDR
Mice homozygous for this mutation lack both protein isoforms, display severe nervous system defects and reveal a previously unknown role of p75NTR in the formation of blood vessels.Abstract:
We identified a protein isoform of the common neurotrophin receptor p75NTR that arises from alternative splicing of exon III in the p75NTR locus. Because this protein is left intact in the previously described p75NTR mutant mouse line1, we generated a new p75NTR mutant allele. Mice homozygous for this mutation lack both protein isoforms, display severe nervous system defects and reveal a previously unknown role of p75NTR in the formation of blood vessels.read more
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Neurotrophins and their receptors: a convergence point for many signalling pathways.
TL;DR: Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
Journal ArticleDOI
Neurotrophin-regulated signalling pathways
TL;DR: Three rare human genetic disorders, which result in deleterious effects on sensory perception, cognition and a variety of behaviours, have been shown to be attributable to mutations in brain-derived neurotrophic factor and two of the Trk receptors.
Journal ArticleDOI
Neurotrophin signaling through the p75 neurotrophin receptor.
TL;DR: It remains a major challenge to link the various p75NTR binding proteins to specific p75nTR-dependent functions, but the identification of p 75NTR interactors and signaling pathways has sparked new directions in p75 NTR research, and will provide a better understanding of this enigmatic receptor.
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The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system.
Georg Dechant,Yves-Alain Barde +1 more
TL;DR: The p75 neurotrophin receptor (p75NTR), a member of the tumor necrosis factor receptor superfamily, associates with the Nogo receptor, a binding protein for axonal growth inhibitors, and appears to be the transducing subunit of this receptor complex.
Journal ArticleDOI
The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI.
TL;DR: In this article, the authors show that the neurotrophin receptor p75(NTR) is involved in the regulation of axonal elongation by neurotrophins as well as several myelin components, including Nogo, myelin-associated glycoprotein (MAG) and myelin oligodendrocyte gly coprotein (OMgp).
References
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Journal ArticleDOI
Embedding in epoxy resins for ultrathin sectioning in electron microscopy.
TL;DR: More rapid than previous techniques, this method gives blocks which do not fracture unduly on trimming and provides sections of soft tissues at 1 μ for phase contrast microscopy, as well as ultrathin sections which cut as easily with glass knives as sections of methacrylate.
Journal ArticleDOI
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
TL;DR: It is demonstrated that src is not required for general cell viability (possibly because of functional overlap with other tyrosine kinases related to src) and an essential role for src in bone formation is uncovered.
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Simplified mammalian DNA isolation procedure.
TL;DR: This work has simplified the standard mammalian DNA isolation procedure with the aim of minimizing the number of manipulations required for each sample.
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Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system.
Kuo-Fen Lee,En Li,L. Julie Huber,Story C. Landis,Arlene H. Sharpe,Moses V. Chao,Rudolf Jaenisch +6 more
TL;DR: In this article, a mouse carrying a mutation of the gene encoding the low affinity NGF receptor p75NGFR was generated by targeted mutation in embryonic stem cells and the defective innervation was correlated with loss of heat sensitivity and associated with the development of ulcers in the distal extremities.
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Gene transfer and molecular cloning of the rat nerve growth factor receptor.
TL;DR: The amino-acid sequence of one form of the receptor for nerve growth factor defines a new class of growth factor receptors, which are distinguished from previous classes of receptors based on their binding to growth factor.