Journal ArticleDOI
Computer aided speckle interferometry: a technique for measuring deformation of the surface of the heart.
Glenn R. Gaudette,Joseph Todaro,Joseph Todaro,Irvin B. Krukenkamp,Irvin B. Krukenkamp,Fu-Pen Chiang,Fu-Pen Chiang +6 more
TLDR
Computer aided speckle interferometry (CASI) is applied to measuring deformation on the epicardial surface of the heart and is a whole field deformation mapping technique that has a spatial resolution three orders of magnitude higher than that of sonomicrometry.Abstract:
An investigation of the inhomogeneous and anisotropic properties of myocardium necessitates a whole field measurement technique with high spatial resolution Computer aided speckle interferometry (CASI) may be applied to measuring deformation on the epicardial surface of the heart Silicone carbide particles (approximately 40 μm in diameter) were sprinkled randomly onto the epicardial surface of isolated rabbit hearts When illuminated with white light, speckles may be observed with a charge coupled device (CCD) camera A balloon was placed in the left ventricle to control the intracavitary load on the arrested heart To compare CASI to the “gold” standard technique of sonomicrometry, two ultrasonic transducers were implanted into the wall of the myocardium Three hearts were exposed to various loading conditions, and at each condition speckle images were recorded CASI was used to determine the distribution of displacement vectors (both direction and magnitude) in the region imaged by the CCD camera Strain along the axis of the implanted transducers was determined with CASI and compared to that obtained with sonomicrometry Strain determined from CASI and sonomicrometry produced equivalent results Unlike sonomicrometry, whereby the displacement between two points with a relatively large gauge length is obtained, CASI is able to determine displacement vectors for hundreds of “points” within the same region In conclusion, CASI produced equivalent results to those obtained from sonomicrometry (although not with the same temporal resolution), but it is a whole field deformation mapping technique that has a spatial resolution three orders of magnitude higher than that of sonomicrometry © 2001 Biomedical Engineering Societyread more
Citations
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Journal ArticleDOI
Two-dimensional digital image correlation for in-plane displacement and strain measurement: a review
TL;DR: In this article, a review of the 2D digital image correlation (2D DIC) technique for displacement field measurement and strain field estimation is presented, and detailed analyses of the measurement accuracy considering the influences of both experimental conditions and algorithm details are provided.
Journal ArticleDOI
Bioengineering Human Myocardium on Native Extracellular Matrix
Jacques P. Guyette,Jonathan M. Charest,Robert W. Mills,Bernhard J. Jank,Philipp T. Moser,Sarah E. Gilpin,Joshua R. Gershlak,Tatsuya Okamoto,Gabriel Gonzalez,David J. Milan,Glenn R. Gaudette,Harald C. Ott +11 more
TL;DR: Native cardiac extracellular matrix scaffolds maintain matrix components and structure to support the seeding and engraftment of human induced pluripotent stem cell-derived cardiomyocytes and enable the bioengineering of functional human myocardial-like tissue of multiple complexities.
Journal ArticleDOI
Tissue-engineered myocardial patch derived from extracellular matrix provides regional mechanical function.
Paul V. Kochupura,Evren U. Azeloglu,Damon J. Kelly,Sergey V. Doronin,Stephen F. Badylak,Irvin B. Krukenkamp,Ira S. Cohen,Glenn R. Gaudette +7 more
TL;DR: At 8 weeks, an ECM-derived tissue-engineered myocardial patch provides regional mechanical function, likely related to cardiomyocyte population, in sharp contrast to Dacron.
Journal ArticleDOI
The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium.
Stephen F. Badylak,Paul V. Kochupura,Ira S. Cohen,Sergey V. Doronin,Adam E. Saltman,Thomas W. Gilbert,Damon J. Kelly,Ronald A. Ignotz,Glenn R. Gaudette +8 more
TL;DR: It is concluded that UBM facilitates a constructive remodeling of myocardial tissue when used as replacement scaffold for excisional defects.
Journal ArticleDOI
Enhanced recovery of mechanical function in the canine heart by seeding an extracellular matrix patch with mesenchymal stem cells committed to a cardiac lineage
Irina A. Potapova,Sergey V. Doronin,Damon J. Kelly,Amy B. Rosen,Adam J.T. Schuldt,Zhongju Lu,Paul V. Kochupura,Richard B. Robinson,Michael R. Rosen,Peter R. Brink,Glenn R. Gaudette,Ira S. Cohen +11 more
TL;DR: The objective of the current study was to determine whether the regenerative effect of ECM could be improved by seeding the patch with human mesenchymal stem cells enhanced to differentiate down a cardiac linage, and to evaluate the ability of these cells to regenerate mechanical function.
References
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Book
Biomechanics: Mechanical Properties of Living Tissues
Yuan-Cheng Fung,Richard Skalak +1 more
TL;DR: This chapter discusses the mechanics of Erythrocytes, Leukocytes, and Other Cells, and their role in Bone and Cartilage, and the properties of Bioviscoelastic Fluids, which are a by-product of these cells.
Journal ArticleDOI
Biomechanics: Mechanical Properties of Living Tissues
Yuan-Cheng Fung,Richard Skalak +1 more
TL;DR: In this article, the authors present a sketch of the history and scope of the field of bio-physiology and discuss the meaning of the Constitutive Equation and the flow properties of blood.
Journal ArticleDOI
Digital Imaging Techniques In Experimental Stress Analysis
W. H. Peters,W. F. Ranson +1 more
TL;DR: In this paper, the surface displacement components in laser speckle metrology were measured using a digital image scanner interfaced to a computer. Butt et al. used a boundary integral equation method to calculate surface traction in the contour.