Journal ArticleDOI
Connectome: How the Brain’s Wiring Makes Us Who We Are
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This article is published in Anesthesia & Analgesia.The article was published on 2013-12-01. It has received 177 citations till now. The article focuses on the topics: Connectome.read more
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Journal ArticleDOI
A mesoscale connectome of the mouse brain
Seung Wook Oh,Julie A. Harris,Lydia Ng,Brent Winslow,Nicholas Cain,Stefan Mihalas,Quanxin Wang,Chris Lau,Leonard Kuan,Alex M. Henry,Marty Mortrud,Benjamin Ouellette,Thuc Nghi Nguyen,Staci A. Sorensen,Clifford R. Slaughterbeck,Wayne Wakeman,Yang Li,David Feng,Anh Ho,Eric Nicholas,Karla E. Hirokawa,Phillip Bohn,Kevin M. Joines,Hanchuan Peng,Michael Hawrylycz,John W. Phillips,John G. Hohmann,Paul Wohnoutka,Charles R. Gerfen,Christof Koch,Amy Bernard,Chinh Dang,Allan R. Jones,Hongkui Zeng +33 more
TL;DR: A brain-wide, cellular-level, mesoscale connectome for the mouse, using enhanced green fluorescent protein-expressing adeno-associated viral vectors to trace axonal projections from defined regions and cell types, and high-throughput serial two-photon tomography to image the EGFP-labelled axons throughout the brain.
Journal ArticleDOI
Individual Variability in Functional Connectivity Architecture of the Human Brain
Sophia Mueller,Sophia Mueller,Danhong Wang,Michael D. Fox,B.T. Thomas Yeo,B.T. Thomas Yeo,Jorge Sepulcre,Mert R. Sabuncu,Rebecca Shafee,Jie Lu,Hesheng Liu +10 more
TL;DR: Using repeated-measurement resting-state functional MRI to explore intersubject variability in connectivity revealed that regions predicting individual differences in cognitive domains are predominantly located in regions of high connectivity variability.
Journal ArticleDOI
The Connectome of a Decision-Making Neural Network
Travis A. Jarrell,Yi Wang,Adam Bloniarz,Christopher A. Brittin,Meng Xu,J. Nichol Thomson,Donna G. Albertson,David H. Hall,Scott W. Emmons +8 more
TL;DR: The wiring diagram of the posterior nervous system of the C. elegans adult male is presented, reconstructed from serial electron micrograph sections, which shows how the network robustly and rapidly selects and executes the steps of a behavioral program on the basis of the inputs from multiple sensory neurons.
Journal ArticleDOI
A critique of pure learning and what artificial neural networks can learn from animal brains.
TL;DR: It is suggested that for AI to learn from animal brains, it is important to consider that animal behaviour results from brain connectivity specified in the genome through evolution, and not due to unique learning algorithms.
Journal ArticleDOI
Human brain networks function in connectome-specific harmonic waves
TL;DR: It is reported that functional networks of thehuman brain are predicted by harmonic patterns, ubiquitous throughout nature, steered by the anatomy of the human cerebral cortex, the human connectome, in a new frequency-specific representation of cortical activity, that is called ‘connectome harmonics’.
References
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CLARITY for mapping the nervous system
Kwanghun Chung,Karl Deisseroth +1 more
TL;DR: Hydrogel-based structures can be built from within biological tissue to allow subsequent removal of lipids without mechanical disassembly of the tissue, creating a tissue-hydrogel hybrid that is physically stable, that preserves fine structure, proteins and nucleic acids, and that is permeable to both visible-spectrum photons and exogenous macromolecules.
Journal ArticleDOI
Prkcz null mice show normal learning and memory.
Anna M. Lee,Benjamin R. Kanter,Dan Dan Wang,Jana P. Lim,Mimi E. Zou,Chichen Qiu,Thomas A. McMahon,Jahan Dadgar,Sarah C. Fischbach-Weiss,Robert O. Messing +9 more
TL;DR: It is shown that absence of PKM-ζ does not impair learning and memory in mice, and that ZIP can erase reward memory even when PKM -ζ is not present.