Coronavirus disease 2019 (COVID-19): An overview of the immunopathology, serological diagnosis and management.
Abubakar Umar Anka,Mohammed Ibrahim Tahir,Sharafudeen Dahiru Abubakar,Mohamed Alsabbagh,Zeineb Zian,Haleh Hamedifar,Araz Sabzevari,Gholamreza Azizi +7 more
TLDR
Treatment approaches to COVID‐19 treatment involve the use of antiviral agents that interfere with the SARS‐CoV‐2 lifecycle to prevent further viral replication and utilizing immunomodulators to dampen the immune system in order to prevent cytokine storm and tissue damage.Citations
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SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism
Romy Kronstein-Wiedemann,Marlena Stadtmüller,Sofia Traikov,Mandy Georgi,M. Teichert,Hesham K. Yosef,Jan Wallenborn,Andreas Karl,Karin Schütze,Michael Wagner,Ali El-Armouche,Torsten Tonn +11 more
TL;DR: In this article , the authors demonstrate that SARS-CoV-2 directly infects erythroid precursor cells, impairs hemoglobin homeostasis and aggravates COVID-19 disease.
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Anticardiolipin and other antiphospholipid antibodies in critically ill COVID-19 positive and negative patients.
Uriel Trahtemberg,Robert Rottapel,Claudia C. dos Santos,Arthur S. Slutsky,Andrew J. Baker,Marvin J. Fritzler +5 more
TL;DR: In this article, the authors found that positive APLA serology was associated with more severe disease regardless of COVID-19 status, while positive aCL was not associated with surrogate markers of thrombosis but ICL was strongly associated with worse disease severity and higher antinuclear antibodies (ANAs).
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An Update on the Pathogenesis of COVID-19 and the Reportedly Rare Thrombotic Events Following Vaccination.
Bulent Kantarcioglu,Omer Iqbal,Jeanine M. Walenga,Bruce E. Lewis,Joseph Lewis,Charles A. Carter,Meharvan Singh,Fabio Lievano,Alfonso Tafur,Eduardo Ramacciotti,Grigoris T. Gerotziafas,Walter Jeske,Jawed Fareed +12 more
TL;DR: In this article, the authors summarized the pathophysiological and thrombotic features of COVID-19 and the safety and efficacy of currently approved CoV-19 vaccines with an aim to clarify the recent concerns of thromboembolic events after CoV19 vaccination.
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COVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical Outcomes
Banafsheh Bigdelou,Mohammad Reza Sepand,Sahar NajafiKhoshnoo,Jorge Alfonso Tavares Negrete,Mohammed S. Sharaf,Jim Q. Ho,Ian D. Sullivan,Prashant Chauhan,M. Etter,Tala Shekarian,Olin D. Liang,Gregor Hutter,Rahim Esfandiarpour,Steven Zanganeh +13 more
TL;DR: This review outlines the putative signaling pathways at the interface of CO VID-19 and several diseases, emphasizing the clinical and molecular implications of concurring diseases in COVID-19 clinical outcomes.
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Reduction of Cardiac Autonomic Modulation and Increased Sympathetic Activity by Heart Rate Variability in Patients With Long COVID
Karina Carvalho Marques,Camilla Costa Silva,Steffany da Silva Trindade,Marcio Clementino de Souza Santos,Rodrigo Santiago Barbosa Rocha,Pedro Fernando da Costa Vasconcelos,Juarez Antônio Simões Quaresma,Luiz Fábio Magno Falcão +7 more
TL;DR: The findings indicate that long COVID leads to sympathetic excitation influence and parasympathetic reduction, which can increase the heart rate and blood pressure and predispose to cardiovascular complications.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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A new coronavirus associated with human respiratory disease in China.
Fan Wu,Su Zhao,Bin Yu,Yan-Mei Chen,Wen Wang,Zhi gang Song,Yi Hu,Zhao Wu Tao,Jun Hua Tian,Yuan Yuan Pei,Ming Li Yuan,Yu Ling Zhang,Fa Hui Dai,Yi Liu,Qi Min Wang,Jiao Jiao Zheng,Lin Xu,Edward C. Holmes,Edward C. Holmes,Yong-Zhen Zhang,Yong-Zhen Zhang +20 more
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.