Journal ArticleDOI
Crosstalk in NF-κB signaling pathways
TLDR
In this paper, a variety of stimuli coalesce on NF-κB activation, which can in turn mediate varied transcriptional programs, and the intricate crosstalk is crucial to shaping the diverse biological functions of NF-KB into cell type-and context-specific responses.Abstract:
NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn mediate varied transcriptional programs. Consequently, NF-κB-dependent transcription is not only tightly controlled by positive and negative regulatory mechanisms but also closely coordinated with other signaling pathways. This intricate crosstalk is crucial to shaping the diverse biological functions of NF-κB into cell type– and context-specific responses.read more
Citations
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Inflammatory responses and inflammation-associated diseases in organs
Linlin Chen,Huidan Deng,Hengmin Cui,Jing Fang,Zhicai Zuo,Junliang Deng,Yinglun Li,Xun Wang,Ling Zhao +8 more
TL;DR: Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds, potentially leading to tissue damage or disease.
Journal ArticleDOI
NF-κB, inflammation, immunity and cancer: coming of age
Koji Taniguchi,Michael Karin +1 more
TL;DR: How the initial discovery of a role for NF-κB in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity is discussed.
Journal ArticleDOI
NF-κB, the first quarter-century: remarkable progress and outstanding questions
Matthew S. Hayden,Sankar Ghosh +1 more
TL;DR: Despite the tremendous progress that has been made in understanding the regulation of NF-κB, there is much that remains to be understood and the fundamental questions that remain unanswered after 25 years of study are highlighted.
Journal ArticleDOI
Getting up to speed with transcription elongation by RNA polymerase II
Iris Jonkers,John T. Lis +1 more
TL;DR: Elongation is recognized as a key phase in the regulation of transcription by Pol II, revealing that elongation is a highly complex process.
Journal ArticleDOI
HMGB1 in Health and Disease
Rui Kang,Ruochan Chen,Qiuhong Zhang,Wen Hou,Sha Wu,Lizhi Cao,Jin Huang,Yan Yu,Xue Gong Fan,Zhengwen Yan,Zhengwen Yan,Xiaofang Sun,Haichao Wang,Qingde Wang,Allan Tsung,Timothy R. Billiar,Herbert J. Zeh,Michael T. Lotze,Daolin Tang +18 more
TL;DR: High-mobility group box 1 (HMGB1), the most abundant and well-studied HMG protein, senses and coordinates the cellular stress response and plays a critical role not only inside of the cell as a DNA chaperone, chromosome guardian, autophagy sustainer, and protector from apoptotic cell death, but also outside thecell as the prototypic damage associated molecular pattern molecule (DAMP).
References
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Journal ArticleDOI
Signaling to NF-kappaB.
Matthew S. Hayden,Sankar Ghosh +1 more
TL;DR: An overview of established NF-kappaB signaling pathways is provided with focus on the current state of research into the mechanisms that regulate IKK activation and NF- kappaB transcriptional activity.
Journal ArticleDOI
Activators and target genes of Rel/NF-kappaB transcription factors.
TL;DR: It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
Journal ArticleDOI
Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.
Journal ArticleDOI
Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes
Olivier Micheau,Jürg Tschopp +1 more
TL;DR: TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal fails to be activated, and the cell survives.