Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies
TLDR
The article presents latest available information on the chemical composition of this plant species and gives a short resume of their beneficial effects in biological systems in vitro, in animals, and in humans, thus underlining their medicinal potential.Abstract:
Schisandra chinensis Turcz. (Baill.) is a plant species whose fruits have been well known in Far Eastern medicine for a long time. However, schisandra seems to be a plant still underestimated in contemporary therapy still in the countries of East Asia. The article presents latest available information on the chemical composition of this plant species. Special attention is given to dibenzo cyclooctadiene lignans. In addition, recent studies of the biological activity of dibenzocyclooctadiene lignans and schisandra fruit extracts are recapitulated. The paper gives a short resume of their beneficial effects in biological systems in vitro, in animals, and in humans, thus underlining their medicinal potential. The cosmetic properties are depicted, too. The analytical methods used for assaying schisandra lignans in the scientific studies and also in industry are also presented. Moreover, special attention is given to the information on the latest biotechnological studies of this plant species. The intention of this review is to contribute to a better understanding of the huge potential of the pharmacological relevance of S. chinensis.read more
Citations
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A review of polysaccharides from Schisandra chinensis and Schisandra sphenanthera: Properties, functions and applications
TL;DR: This review summarizes the physicochemical properties and biological functions of polysaccharides from two Schisandra fruits, and the application prospects of these bioactive macromolecules in future daily life and medicine.
Structural identification
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An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis
TL;DR: The experimental findings support the extracts and lignan components from S. chinensis can be used as new therapeutic agents to treat various neurodegenerative diseases and are highlighted as promising resources for the development of natural and effective agents for neuroprotective and cognitive enhancement effects.
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Lignans and Their Derivatives from Plants as Antivirals
TL;DR: Two types of antiviral lignan—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B in clinical, serve as examples of using lignans for antivirals—are discussed in some detail.
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Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions.
Muhammad Ali,Tariq Khan,Tariq Khan,Kaneez Fatima,Qurat ul Ain Ali,Muhammad Ovais,Ali Talha Khalil,Ikram Ullah,Abida Raza,Zabta Khan Shinwari,Muhammad Idrees,Muhammad Idrees +11 more
TL;DR: The present review focuses on the composition, pharmacology, and results of experimental trials of selected medicinal plants, finding that further research is needed to identify, characterize, and standardize the active ingredients, useful compounds, and their preparations for the treatment of liver diseases.
References
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Journal Article
Lignans in Schisandra chinensis in vitro cultures.
Agnieszka Szopa,Halina Ekiert +1 more
TL;DR: This is the first report on the quantitative analysis of schis androl A and schisandrol B in Schisandra chinensis in vitro cultures using an HPLC method.
Journal ArticleDOI
Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma
Su Youn Yim,You Jin Lee,Yoen Kyung Lee,Seung Eun Jung,Ji Ha Kim,Hak-Jin Kim,Beung-Gu Son,Young-Hoon Park,Young Guen Lee,Young-Whan Choi,Dae Youn Hwang +10 more
TL;DR: Results suggest that gomisin N is an anti-cancer drug candidate capable of inhibiting the proliferation and inducing the apoptosis of human hepatic carcinomas.
Journal ArticleDOI
The Protecting Effect of Deoxyschisandrin and Schisandrin B on HaCaT Cells against UVB-Induced Damage
TL;DR: The results imply that the antioxidants SA and SB could protect cells from UVB-induced cell damage via scavenging ROS.
Journal ArticleDOI
Dibenzocyclooctadiene lignans from Schisandra chinensis and their inhibitory activity on NO production in lipopolysaccharide-activated microglia cells.
TL;DR: In vitro activity assays showed that 11 of the 14 compounds exhibited inhibitory activity on lipopolysaccharide (LPS)-induced NO release in primary murine BV2 microglia cells.
Journal ArticleDOI
Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity
Han-Wei Liu,Xiu-Zhu Yu,Daniele Padula,Gennaro Pescitelli,Zhi-Wei Lin,Fei Wang,Kai Ding,Ming Lei,Jin-Ming Gao +8 more
TL;DR: Natural lignans and semisynthetic schisantherin A derivatives showed the antiproliferative activity on four human cancer cell lines and Id1 (an inhibitor of DNA binding protein) and estrogenic potency and compounds 5, 7, and 8 exhibited very potent estrogenic activity.
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