Cutaneous Squamous Cell Carcinoma of the Head and Neck
Vivek V. Gurudutt,Eric M. Genden +1 more
TLDR
The diagnosis, pathology, clinical course, and treatment options for cutaneous squamous cell carcinoma of the head and neck are examined.Abstract:
Cutaneous squamous cell carcinoma of the head and neck is an epidemic that reaches all parts of the world. Making the diagnosis relies on the acumen of the clinician and pathologist. Various pathologic subtypes exist and differ in histology and prognosis. High-risk tumors need aggressive treatment and vigilant surveillance to monitor for recurrence. Large tumors, deep tissue invasion, perineural involvement, recurrence, location in high-risk areas, and immunosuppression are implicated in worsening prognosis. Surgery is the mainstay of treatment with adjuvant radiation therapy as needed for aggressive tumors; however, other modalities are potentially useful for low-risk lesions. The use of Mohs surgery has become increasingly useful and has shown high success rates. Involvement of parotid and neck lymph nodes significantly affects outcomes and the physician should be comfortable with management of this complex disease. This paper examines the diagnosis, pathology, clinical course, and treatment options for cutaneous squamous cell carcinoma of the head and neck.read more
Citations
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Overview of the 8th Edition TNM Classification for Head and Neck Cancer
Shao Hui Huang,Brian O'Sullivan +1 more
TL;DR: The recently published 8th edition TNM classification institutes the following changes to the staging of head and neck: new stage classifications [HPV-related oropharyngeal cancer (HPV+ OPC) and soft tissue sarcoma of theHead and neck (HN-STS)] and modification of T and N categories.
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Basal cell and squamous cell skin cancers.
Stanley J. Miller,Murad Alam,James S. Andersen,Daniel Berg,Christopher K. Bichakjian,Glen M. Bowen,Richard T. Cheney,L. Frank Glass,Roy C. Grekin,Anne Kessinger,Nancy Y. Lee,Nanette J. Liégeois,Daniel D. Lydiatt,Jeff M. Michalski,William H. Morrison,Kishwer S. Nehal,Kelly C. Nelson,Paul Nghiem,Thomas Olencki,Clifford S. Perlis,E. William Rosenberg,Ashok R. Shaha,Marshall M. Urist,Linda C. Wang,John A. Zic +24 more
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Update on Keratinocyte Carcinomas
TL;DR: Keratinocyte Carcinomas Squamous-cell and basal-cell carcinomas of the skin are increasing in frequency and are responsive to inhibition of the hedgehog pathway.
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Cutaneous squamous cell carcinoma: Management of advanced and high-stage tumors
TL;DR: The second article in this continuing medical education series addresses in question and answer format the most common questions related to advanced and high-stage cutaneous squamous cell carcinomas, with a simplified flowchart as mentioned in this paper.
Journal ArticleDOI
Autophagy Inhibitor Chloroquine Enhanced the Cell Death Inducing Effect of the Flavonoid Luteolin in Metastatic Squamous Cell Carcinoma Cells
Lien Verschooten,Kathleen Barrette,Sofie Van Kelst,Noemí Rubio Romero,Charlotte M. Proby,Rita Vos,Patrizia Agostinis,Marjan Garmyn +7 more
TL;DR: In vitro treatment with the flavonoid Luteolin induced caspase-dependent cell death in a model of human cutaneous squamous cell carcinoma (SCC) derived cells, representing a matched pair of primary tumor and its metastasis, suggesting that Lutesin has the capacity to induce selectively apoptotic cell death both in primary cutaneous S CC cells and in metastatic SCC cells in combination with chloroquine, an inhibitor of autophagosomal degradation.
References
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