Book ChapterDOI
CXCL8 Signaling in the Tumor Microenvironment.
TLDR
The upregulation of CXCL8 at the tumor invasion front in several human cancers suggests its interplay between the tumor and its microenvironment rendering tumor progression by enhancing angiogenesis, tumor genetic diversity, survival, proliferation, immune escape, metastasis, and multidrug resistance.Abstract:
The tumor microenvironment represents a dynamic and complex cellular network involving intricate communications between the tumor and highly heterogeneous groups of cells, including tumor-supporting immune and inflammatory cells, cancer-associated fibroblasts, endothelial cells, tumor-associated macrophages, adipose cells, and pericytes. Associated with a variety of growth factors, chemokines, cytokines, and other signaling molecules, the interaction between the tumor microenvironment and the tumor cells empowers aggressiveness of tumor by enhancing its survivability. CXCL8 (also known as Interleukin 8), a multifunctional proinflammatory chemokine that was initially classified as a neutrophil chemoattractant, recently has been found to be a key contributor in tumorigenesis. The upregulation of CXCL8 at the tumor invasion front in several human cancers suggests its interplay between the tumor and its microenvironment rendering tumor progression by enhancing angiogenesis, tumor genetic diversity, survival, proliferation, immune escape, metastasis, and multidrug resistance. The autocrine and paracrine modulation of CXCL8 via the chemokine receptors CXCR1/2 promotes several intracellular signaling cascades that fosters tumor-associated inflammation, reprogramming, epithelial-mesenchymal transition, and neovascularization. Hence, decrypting the regulatory/signaling cascades of CXCL8 and its downstream effects may harbor prognostic clinical prospects of a tumor microenvironment-oriented cancer therapeutics.read more
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Journal ArticleDOI
Cancer-Associated Fibroblasts Influence the Biological Properties of Malignant Tumours via Paracrine Secretion and Exosome Production
TL;DR: The role of exosomes as mediators of the dialogue between cancer cells and cancer-associated fibroblasts is discussed together with their therapeutic relevance and the functional unity of the paracrine- and exosome-mediated communication of cancer cells with the tumour microenvironment represented by CAFs is worthy of attention.
Journal ArticleDOI
MDACT: A New Principle of Adjunctive Cancer Treatment Using Combinations of Multiple Repurposed Drugs, with an Example Regimen
Richard E. Kast,Alex Alfieri,Hazem I. Assi,Terry C. Burns,Ashraf Elyamany,Maria Gonzalez-Cao,Georg Karpel-Massler,Christine Marosi,Michael Salacz,Iacopo Sardi,Pieter Van Vlierberghe,Mohamed S. Zaghloul,Marc-Eric Halatsch +12 more
TL;DR: The details of how an example six drug regimen, when added alongside of current traditional treatments, might inhibit enough of the eight core growth driving elements to allow those standard treatments to be more effective are shown.
Journal ArticleDOI
Longitudinal plasma proteomic profiling of patients with non-small cell lung cancer undergoing immune checkpoint blockade
Michal Harel,Coren Lahav,Eyal Jacob,Nili Dahan,I Sela,Yehonatan Elon,Shani Raveh Shoval,Galit Yahalom,Iris Kamer,Alona Zer,Ofer Sharon,David P. Carbone,Adam P. Dicker,Jair Bar,Yuval Shaked +14 more
TL;DR: This study reveals potential biomarkers in blood plasma for predicting response to ICI therapy in patients with NSCLC and sheds light on mechanisms underlying therapy resistance.
Journal ArticleDOI
Angiogenesis, Lymphangiogenesis, and Inflammation in Chronic Obstructive Pulmonary Disease (COPD): Few Certainties and Many Outstanding Questions
Remo Poto,Stefania Loffredo,Francesco Palestra,Gianni Marone,Vincenzo Patella,Gilda Varricchi +5 more
TL;DR: Although there is evidence that alterations of angiogenesis and, to a lesser extent, lymphangiogenesis, are associated with COPD, there are still many unanswered questions.
Journal ArticleDOI
The AGEs/RAGE Transduction Signaling Prompts IL-8/CXCR1/2-Mediated Interaction between Cancer-Associated Fibroblasts (CAFs) and Breast Cancer Cells
Maria Francesca Santolla,Marianna Talia,Francesca Cirillo,Domenica Scordamaglia,Salvatore De Rosis,Asia Spinelli,Anna Miglietta,Bruno Nardo,Gianfranco Filippelli,Ernestina Marianna De Francesco,Antonino Belfiore,Rosamaria Lappano,Marcello Maggiolini +12 more
TL;DR: New insights are provided on the involvement of IL-8 in the AGEs/RAGE transduction pathway among the intricate connections linking breast cancer cells to the surrounding stroma and may pave the way for further investigations to define the role ofIL-8 as useful target for the better management of breast cancer patients exhibiting metabolic disorders.
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