Journal ArticleDOI
Cyclic AMP response element-binding protein (CREB) phosphorylation: a mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics.
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TLDR
An experimental strategy is described to biochemically characterize the pharmacological induction of CREB phosphorylation as a mechanistic marker across different pharmacological classes of compounds for the potential treatment of AD that include: α7 nicotinic agonists, H3 antagonists and 11β HSD1 inhibitors.About:
This article is published in Biochemical Pharmacology.The article was published on 2012-03-15. It has received 135 citations till now. The article focuses on the topics: CREB & CREB in cognition.read more
Citations
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The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease.
Josiane Budni,Tatiani Bellettini-Santos,Francielle Mina,Michelle Lima Garcez,Alexandra I. Zugno +4 more
TL;DR: Considering that aging and AD are related to cognitive impairment, here it is discussed the involving of neurotrophic factors in the aging process and AD.
Journal ArticleDOI
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies.
Piyoosh Sharma,Pavan Srivastava,Ankit Seth,Prabhash Nath Tripathi,Anupam G. Banerjee,Sushant K. Shrivastava +5 more
TL;DR: The present review provides an insight to the different molecular mechanisms involved in the development and progression of the AD and potential therapeutic strategies, enlightening perceptions into structural information of conventional and novel targets along with the successful applications of computational approaches for the design of target-specific inhibitors.
Journal ArticleDOI
Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles.
TL;DR: The study underlines the importance of SD as a chronic stressor, which by modulating biochemical processes influences the development of memory impairments and AD neuropathologies and Correction of SD could be a viable therapeutic strategy to prevent the onset or slow the progression of AD in individuals bearing this risk factor.
Journal ArticleDOI
Alzheimer's Disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms
TL;DR: The current work suggesting that neuronal differentiation is defective in Alzheimer's disease, leading to dysfunction of the dentate gyrus is reviewed, and alterations in critical signals regulating neurogenesis, such as presenilin-1, Notch 1, soluble amyloid precursor protein, CREB, and β-catenin underlie dysfunctional neuroGenesis in Alzheimer’s disease are reviewed.
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GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression
Pláteník J,Zdeněk Fišar,Richard Buchal,Roman Jirák,Eva Kitzlerová,Martina Zvěřová,Jiří Raboch +6 more
TL;DR: It is demonstrated that AD is accompanied by increased CREB activity in lymphocytes and a decreased concentration of BDNF in platelet-rich plasma, which appears to correlate with moderate to severe stages of dementia in AD.
References
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Journal ArticleDOI
Memory--a century of consolidation.
TL;DR: This review examines the progress made over the century in understanding the time-dependent processes that create the authors' lasting memories.
Journal ArticleDOI
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals.
TL;DR: The molecular mechanisms by which Ser133-phosphorylated CREB activates transcription, intracellular signaling pathways that lead to phosphorylation ofCREB at Ser133, and features of each signaling pathway that impart specificity at the level of CREB activation are discussed.
Journal ArticleDOI
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
Roussoudan Bourtchuladze,Bruno G. Frenguelli,Julie A. Blendy,Diana Cioffi,Günther Schütz,Alcino J. Silva +5 more
TL;DR: Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation, however, paired-pulse facilitation and posttetanic potentiation are normal.
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Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor.
TL;DR: It is shown here that histamine inhibits its own release from depolarized slices of rat cerebral cortex, an action apparently mediated by a class of receptor (H3) pharmacologically distinct from those previously characterized, that is, the H1 and H2 receptors.
Journal ArticleDOI
Creb and memory
TL;DR: Evidence from Aplysia, Drosophila, mice, and rats shows that CREB-dependent transcription is required for the cellular events underlying long-term but not short-term memory, indicating thatCREB may be a universal modulator of processes required for memory formation.
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