Journal ArticleDOI
Cytokine production and hematopoiesis supporting activity of cord blood-derived unrestricted somatic stem cells.
Gesine Kögler,Teja Falk Radke,Aurélie Lefort,Sandra Sensken,Johannes C. Fischer,Rüdiger V. Sorg,Peter Wernet +6 more
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TLDR
USSC produce functionally significant amounts of hematopoiesis-supporting cytokines and are superior to BMMSC in expansion of CD34+ cells from CB and are therefore a suitable candidate for stroma-driven ex vivo expansion of heMatopoietic CB cells for short-term reconstitution.About:
This article is published in Experimental Hematology.The article was published on 2005-05-01. It has received 172 citations till now. The article focuses on the topics: Cord blood.read more
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Mesenchymal stem cells in health and disease
TL;DR: The targets and mechanisms of M SC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches are discussed.
Journal ArticleDOI
Correction: Corrigendum: The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes
Jing Guo,Fengming Huang,Jun Liu,Yu Chen,Wei Wang,Bin Cao,Zhen Zou,Song Liu,Jingcao Pan,Changjun Bao,Mei Zeng,Haixia Xiao,Hainv Gao,Shigui Yang,Yan Zhao,Qiang Liu,Huandi Zhou,Jingdong Zhu,Xiaoli Liu,Weifeng Liang,Yida Yang,Shufa Zheng,Jiezuan Yang,Hongyan Diao,Kunkai Su,Li Shao,Hongcui Cao,Ying Wu,Min Zhao,Shuguang Tan,Hui Li,Xiaoqing Xu,Chunmei Wang,Jianmin Zhang,Li Wang,Jianwei Wang,Jun Xu,Dangsheng Li,Nanshan Zhong,Xuetao Cao,George F. Gao,Lanjuan Li,Chengyu Jiang +42 more
TL;DR: This Article contains typographical errors in Table 2 where ‘Week 2 (N = 32)’ was incorrectly given as ‘week (n’=2’.
Journal ArticleDOI
Human Umbilical Cord Matrix Stem Cells: Preliminary Characterization and Effect of Transplantation in a Rodent Model of Parkinson's Disease
Mark L. Weiss,Satish Medicetty,Amber R. Bledsoe,Raja Shekar Rachakatla,Michael Choi,Shosh Merchav,Yongquan Luo,Mahendra S. Rao,Gopalrao V.N. Velagaleti,Deryl L. Troyer +9 more
TL;DR: The umbilical cord matrix appears to be a rich, noncontroversial, and inexhaustible source of primitive mesenchymal stem cells.
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Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche
Lizzia Raffaghello,Giordano Bianchi,Maria Bertolotto,Fabrizio Montecucco,Alessandro Busca,Franco Dallegri,Luciano Ottonello,Vito Pistoia +7 more
TL;DR: In the bone marrow niche, MSC likely protect neutrophils of the storage pool from apoptosis, preserving their effector functions and preventing the excessive or inappropriate activation of the oxidative metabolism, and a novel mechanism whereby the inflammatory potential of activated neutrophil is harnessed by inhibition of apoptosis and reactive oxygen species production without impairing phagocytosis and chemotaxis has been identified.
Journal ArticleDOI
Mesenchymal stem cells: a new strategy for immunosuppression?
TL;DR: It is possible that some of the beneficial effects of MSCs might reflect, in part, the trophic and protective activities they exert on injured cells and tissues, rather than resulting from a true transdifferentiation.
References
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Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Notch Signaling: Cell Fate Control and Signal Integration in Development
TL;DR: Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.
Journal ArticleDOI
Mesenchymal progenitor cells in human umbilical cord blood.
TL;DR: The results suggest that preterm, as compared with term, cord blood is richer in mesenchymal progenitors, similar to haematopoietic progenitor cells.
Journal ArticleDOI
Mesenchymal stem cells: Biology and potential clinical uses
TL;DR: Preclinical and early clinical safety studies are paving the way for further applications of mesenchymal stem cells in the field of transplantation with respect to hematopoietic support, immunoregulation, and graft facilitation.
Journal ArticleDOI
Outcomes among 562 Recipients of Placental-Blood Transplants from Unrelated Donors
Pablo Rubinstein,Carmelita Carrier,Andromachi Scaradavou,Joanne Kurtzberg,John W. Adamson,Anna Rita Migliaccio,Richard L. Berkowitz,Michael F. Cabbad,Dobrila Nl,Patricia E. Taylor,Richard E. Rosenfield,Cladd E. Stevens +11 more
TL;DR: Placental blood is a useful source of allogeneic hematopoietic stem cells for bone marrow reconstitution and is associated with the severity of GVHD, type of leukemia, and stage of the disease.