Journal ArticleDOI
d-Amino acid oxidase knockdown in the mouse cerebellum reduces NR2A mRNA
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TLDR
The utility of lentiviruses to deliver RNAi to glial cells within the cerebellum, and the role of DAO in D-serine metabolism are confirmed, provide a tool to investigate DAO, an enzyme currently of considerable interest in the pathophysiology and therapy of schizophrenia.About:
This article is published in Molecular and Cellular Neuroscience.The article was published on 2011-01-01. It has received 21 citations till now. The article focuses on the topics: Gene knockdown & Serine.read more
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Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine
Helene M. Savignac,Giulia Corona,Henrietta Mills,Li Chen,Jeremy P. E. Spencer,George Tzortzis,Philip W.J. Burnet +6 more
TL;DR: The GOS prebiotic increased cortical NR1, d-serine, and hippocampal NR2A subunits and BDNF and NR1subunit mRNAs, in the rat hippocampus, and increased plasma levels of the gut peptide PYY.
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Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus
Matildé Le Bail,Magalie Martineau,Silvia Sacchi,Natalia Yatsenko,Inna Radzishevsky,Sandrine Conrod,Karima Ait Ouares,Herman Wolosker,Loredano Pollegioni,Jean-Marie Billard,Jean-Pierre Mothet +10 more
TL;DR: An unprecedented relationship in the identity of the coagonist not only with the GluN2 subunit composition at synaptic NMDARs but also with astrocyte activity in the developing and mature hippocampus that reconciles the complementary functions of d-serine and glycine in modulating N MDARs during the maturation of tripartite glutamatergic synapses is disclosed.
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D-serine as a gliotransmitter and its roles in brain development and disease
TL;DR: The evidence that D-serine is actively released by glial cells is considered and the studies that have implicated D-Serine as a critical player involved in regulating NMDAR-mediated synaptic transmission and neuronal migration during development are examined.
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Schizophrenia: do all roads lead to dopamine or is this where they start? Evidence from two epidemiologically informed developmental rodent models
TL;DR: In this paper, the authors summarize convergent evidence from two well-described developmental animal models, namely maternal immune activation and developmental vitamin D deficiency, that begin to address this question and suggest that rather than all roads leading to DA, perhaps, this may be where they start.
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Adjunctive sarcosine plus benzoate improved cognitive function in chronic schizophrenia patients with constant clinical symptoms: A randomised, double-blind, placebo-controlled trial
Chun-Yuan Lin,Sun-Yuan Liang,Yue-Cune Chang,Shuo-Yen Ting,Ching-Ling Kao,Yu-Hsin Wu,Guochuan E. Tsai,Hsien-Yuan Lane +7 more
TL;DR: This finding suggests N-methyl-d-aspartate receptor-enhancement therapy can improve the cognitive function of patients with schizophrenia, further indicating this pro-cognitive effect can be primary without improvement in clinical symptoms.
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
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Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence.
TL;DR: This review critically summarizes the neuropathology and genetics of schizophrenia, the relationship between them, and speculates on their functional convergence via an influence upon synaptic plasticity and the development and stabilization of cortical microcircuitry.
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D-serine added to antipsychotics for the treatment of schizophrenia
TL;DR: A significant improvement in patients who received D-serine treatment revealed significant improvements in their positive, negative, and cognitive symptoms as well as some performance in Wisconsin Card Sorting Test (WCST).
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Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi
Jodi L. McBride,Ryan L. Boudreau,Scott Q. Harper,Scott Q. Harper,Patrick D. Staber,Alex Mas Monteys,Inâs Martins,Brian L. Gilmore,Haim Burstein,Richard W. Peluso,Barry A. Polisky,Barrie J. Carter,Beverly L. Davidson +12 more
TL;DR: It is demonstrated that the robust levels of antisense RNAs emerging from shRNA expression systems can be problematic in the mouse brain, and miRNA-based approaches may provide more appropriate biological tools for expressing inhibitory RNAs in the brain.
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Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia
TL;DR: There is convincing evidence that hypofunction of a subset of NMDA receptors may contribute to the symptomatic features of schizophrenia.