Journal ArticleDOI
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
Sonja I. Gringhuis,Tanja M. Kaptein,Brigitte A. Wevers,Bart Theelen,Michiel van der Vlist,Teun Boekhout,Teunis B. H. Geijtenbeek +6 more
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TLDR
The authors showed that dectin-1 signaling in response to fungi and mycobacteria induces IL-1β maturation via a noncanonical caspase-8-dependent inflammasome.Abstract:
Production of the proinflammatory cytokine IL-1β is crucial in host defense. Geijtenbeek and colleagues show that dectin-1 signaling in response to fungi and mycobacteria induces IL-1β maturation via a noncanonical caspase-8-dependent inflammasome.read more
Citations
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Activation and regulation of the inflammasomes
TL;DR: The complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response are discussed, and the similarities to another molecular signalling platform — the apoptosome — that monitors cellular health are highlighted.
Journal ArticleDOI
Inflammasomes: mechanism of action, role in disease, and therapeutics
TL;DR: Increasing evidence in mouse models strongly implicates an involvement of the inflammasome in the initiation or progression of diseases with a high impact on public health, such as metabolic disorders and neurodegenerative diseases.
Journal ArticleDOI
Innate immune pattern recognition: a cell biological perspective.
TL;DR: This review highlights aspects of cell biology in pattern-recognition receptor signaling by focusing on signals that originate from the cell surface, from endosomal compartments, and from within the cytosol.
Immunity to Fungal Infections
TL;DR: The nature and function of the immune response to fungi is an exciting challenge that might set the stage for new approaches to the treatment of fungal diseases, from immunotherapy to vaccines.
Journal ArticleDOI
Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis
Iliyan D. Iliev,Vincent Funari,Vincent Funari,Kent D. Taylor,Quoclinh Nguyen,Christopher N. Reyes,Samuel P. Strom,Jordan Brown,Courtney A. Becker,Phillip Fleshner,Marla Dubinsky,Jerome I. Rotter,Hanlin L. Wang,Dermot P.B. McGovern,Gordon D. Brown,David M. Underhill,David M. Underhill +16 more
TL;DR: It is shown that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1, which substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease.
References
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Donald W. Nicholson,Ambereen Ali,Nancy A. Thornberry,John P. Vaillancourt,C K Ding,Michel Gallant,Yves Gareau,Patrick R. Griffin,Marc Labelle,Yuri Lazebnik +9 more
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TL;DR: The mammalian immune system has innate and adaptive components, which cooperate to protect the host against microbial infections, and recent progress brings us closer to an integrated view of the immune system and its function in host defence.
Journal ArticleDOI
Non-canonical inflammasome activation targets caspase-11
Nobuhiko Kayagaki,Søren Warming,Mohamed Lamkanfi,Lieselotte Vande Walle,Salina Louie,Jennifer Dong,Kim Newton,Yan Qu,Jinfeng Liu,Sherry Heldens,Juan Zhang,Wyne P. Lee,Merone Roose-Girma,Vishva M. Dixit +13 more
TL;DR: It is shown, with C57BL/6 Casp11 gene-targeted mice, that caspase-11 is critical for casp enzyme-1 activation and IL-1β production in macrophages infected with Escherichia coli, Citrobacter rodentium or Vibrio cholerae, and a unique pro-inflammatory role for casingase- 11 in the innate immune response to clinically significant bacterial infections is highlighted.
Journal ArticleDOI
The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
TL;DR: The effector cytokines of Th17 cells mediate the crucial crosstalk between immune system and tissues, and play indispensable roles in tissue immunity.