Depletion of Pre-β-high Density Lipoprotein by Human Chymase Impairs ATP-binding Cassette Transporter A1- but Not Scavenger Receptor Class B Type I-mediated Lipid Efflux to High Density Lipoprotein
Elda Favari,Miriam Lee,Laura Calabresi,Guido Franceschini,Francesca Zimetti,Franco Bernini,Petri T. Kovanen +6 more
TLDR
The results indicate that chymase treatment of HDL3 specifically impairs the ABCA1-dependent pathway without influencing either aqueous or SR-BI-facilitated diffusion and that this effect is caused by depletion of lipid-poor pre-β-migrating particles in HDL3.About:
This article is published in Journal of Biological Chemistry.The article was published on 2004-03-12 and is currently open access. It has received 124 citations till now. The article focuses on the topics: ABCA1 & ATP Binding Cassette Transporter 1.read more
Citations
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Journal ArticleDOI
The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages
Margarita de la Llera-Moya,Denise Drazul-Schrader,Bela F. Asztalos,Marina Cuchel,Daniel J. Rader,George H. Rothblat +5 more
TL;DR: It is found that independently of HDL-C, sera with higher efflux capacity had a significant increase in ABCA1-mediated efflux, which was significantly correlated to the concentration of pre&bgr;-1 HDL.
Cell Biology/Signaling The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages
Margarita de la Llera-Moya,Denise Drazul-Schrader,Bela F. Asztalos,Marina Cuchel,Daniel J. Rader,George H. Rothblat +5 more
TL;DR: In this article, the authors measured efflux from macrophages to apolipoprotein B-depleted serum from 263 specimens and found instances in which serum having similar high-density lipoprotein cholesterol (HDL-C) differed in their efflux capacity.
Journal ArticleDOI
Paradoxical Association of Enhanced Cholesterol Efflux With Increased Incident Cardiovascular Risks
Xinmin S. Li,W.H. Wilson Tang,Marian K. Mosior,Ying Huang,Yuping Wu,William Matter,Vivian Gao,David Schmitt,Joseph A. DiDonato,Edward A. Fisher,Jonathan D. Smith,Stanley L. Hazen +11 more
TL;DR: Heightened cholesterol efflux to apoB-depleted serum was paradoxically associated with increased prospective risk for myocardial infarction, stroke, and death, and the majority of released radiolabeled cholesterol from macrophages in cholesterol eff Lux activity assays does not reside within a high-density lipoprotein particle.
Journal ArticleDOI
Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages.
TL;DR: The presence of distinct pathways for cholesterol efflux to lipid-free apolipoprotein AI and phospholipid-containing HDL species clarifies the understanding of reverse cholesterol transport, and provides new opportunities for its therapeutic manipulation.
Journal ArticleDOI
Cardiovascular disease risk reduction by raising HDL cholesterol--current therapies and future opportunities
TL;DR: The biology of HDL particles, the established and future therapeutic options to increase HDL‐C, the results and conclusions of the most important studies published in the last years and an outlook on future diagnostic tools and therapeutic opportunities regarding coronary artery disease are given.
References
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Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
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Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.
H. Schägger,G. von Jagow +1 more
TL;DR: A discontinuous sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) system for the separation of proteins in the range from 1 to 100 kDa is described, and the omission of glycine and urea prevents disturbances which might occur in the course of subsequent amino acid sequencing.
Journal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
TL;DR: Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.
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Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
TL;DR: The cholesteryl Ester/Protein Complexes from Atherosclerotic Plaques and the Foam Cell in Familial Hypercholesterolemia are studied.
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Molecular physiology of reverse cholesterol transport.
TL;DR: The removal of cholesterol from cells, like its delivery, appears to be specific and well regulated, and RCT can now be understood in molecular terms.
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