Journal ArticleDOI
Design of a triangular platform piezoresistive affinity microcantilever sensor for biochemical sensing applications
Ribu Mathew,A. Ravi Sankar +1 more
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TLDR
In this paper, a triangular cantilever platform with integrated piezoresistors was proposed for biochemical sensing applications, and its performance was evaluated in terms of the figure of merit (FoM) and measurement bandwidth.Abstract:
Microcantilever platforms with integrated piezoresistors have found versatile applications in the field of clinical analysis and diagnostics. Even though treatise encompasses numerous design details of the cantilever based biochemical sensors, a majority of them focus on the generic slender rectangular cantilever platform mainly due to its evolution from the atomic force microscope (AFM). The reported designs revolve around the aspects of dimensional optimization and variations with respect to the combination of materials for the composite structure. In this paper, a triangular cantilever platform is shown to have better performance metrics than the reported generic slender rectangular and the square cantilever platforms with integrated piezoresistors for biochemical sensing applications. The selection and optimization of the triangular cantilever platform is carried out in two stages. In the first stage, the preliminary selection of the cantilever shape is performed based on the initial design obtained by analytical formulae and numerical simulations. The second stage includes the geometrical optimization of the triangular cantilever platform and the integrated piezoresistor. The triangular cantilever platform shows a better performance in terms of the figure of merit (FoM), and the measurement bandwidth. The simulation results show that the magnitude of ψ of the triangular platform is 77.21% and 65.64% higher than that of the slender rectangular and the square cantilever platforms respectively. Moreover, the triangular platform exhibits a measurement bandwidth that is 70.91% and 2.04 times higher than that of the slender rectangular and square cantilever structures respectively. For a better understanding of the 2D nature of the stress generated on the cantilever platform due to the surface stress, its spatial profile has been extracted and depicted graphically. Finally, a set of design rules are provided for optimizing the triangular cantilever platform and piezoresistor dimensions in terms of the electrical sensitivity and the mechanical stability for biochemical sensing applications.read more
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A Review on Surface Stress-Based Miniaturized Piezoresistive SU-8 Polymeric Cantilever Sensors
Ribu Mathew,A. Ravi Sankar +1 more
TL;DR: This review article would serve as a guideline for researchers to understand specifics and functionality of surface stress-based piezoresistive SU-8 polymeric cantilever sensors.
Journal ArticleDOI
Clinically relevant analytical techniques, organizational concepts for application and future perspectives of point-of-care testing
TL;DR: The underlying emerging techniques that are based on advanced microfluidics and nanomaterials, device miniaturization, and multiplexing the detection mode are described, contributing significantly to the future perspectives of this nascent diagnostic modality.
Journal ArticleDOI
Performance comparison of a single element piezoresistor with a half-active Wheatstone bridge for miniaturized pressure sensors
TL;DR: In this paper, the performance of a single element piezoresistor (3TP-1) is compared with a half-active WSB configuration and other single element PAs, such as four terminal PAs (4TP), multi-terminal PAs(MTP), and another three terminal PEs(3TP) for area constrained applications.
Journal ArticleDOI
In silico modeling and investigation of self-heating effects in composite nano cantilever biosensors with integrated piezoresistors
Ribu Mathew,A. Ravi Sankar +1 more
TL;DR: In this article, the effect of self-heating on the thermo-electro-mechanical response of piezoresistive nano cantilever sensors as a function of the relative geome is investigated.
References
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Journal ArticleDOI
What is the Young's Modulus of Silicon?
TL;DR: In this paper, the authors present the best known elasticity data for silicon, both in depth and in a summary form, so that it may be readily accessible to MEMS designers.
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A review of the recent research on vibration energy harvesting via bistable systems
Ryan L. Harne,Kon-Well Wang +1 more
TL;DR: A review of the major efforts and findings documented in the literature can be found in this article, where a common analytical framework for bistable electromechanical dynamics is presented, the principal results are provided, the wide variety of bistably energy harvesters are described, and some remaining challenges and proposed solutions are summarized.
Journal ArticleDOI
Comparative advantages of mechanical biosensors
TL;DR: The general issues that will be critical to the success of any type of next-generation mechanical biosensor are explained, such as the need to improve intrinsic device performance, fabrication reproducibility and system integration, and the need for a greater understanding of analyte-sensor interactions on the nanoscale.
Journal ArticleDOI
A graphical representation of the piezoresistance coefficients in silicon
TL;DR: The longitudinal and transverse piezoresistance coefficients at room temperature are plotted as a function of the crystal directions for orientations in the lattice in this article, where the crystal orientation is assumed to be orthogonal.
Journal ArticleDOI
Label-free protein assay based on a nanomechanical cantilever array
Youri Arntz,Johannes D. Seelig,Hans Peter Lang,Hans Peter Lang,J. Zhang,Patrick Hunziker,J.-P. Ramseyer,Ernst Meyer,Martin Hegner,C. Gerber,C. Gerber +10 more
TL;DR: Both myoglobin and creatin kinase could be detected independently using cantilevers functionalized with the corresponding antibodies, in unspecific protein background, and this approach permits the use of up to seven different antigen–antibody reactions simultaneously, including an additional thermomechanical and chemical in situ reference.