Journal ArticleDOI
Designed protein- and peptide-based hydrogels for biomedical sciences
TLDR
A review of protein-and peptide-based hydrogels can be found in this paper, where the authors discuss the potential of using protein or peptide based hydrogel in the field of biomedical sciences.Abstract:
Proteins are fundamentally the most important macromolecules for biochemical, mechanical, and structural functions in living organisms. Therefore, they provide us with diverse structural building blocks for constructing various types of biomaterials, including an important class of such materials, hydrogels. Since natural peptides and proteins are biocompatible and biodegradable, they have features advantageous for their use as the building blocks of hydrogels for biomedical applications. They display constitutional and mechanical similarities with the native extracellular matrix (ECM), and can be easily bio-functionalized via genetic and chemical engineering with features such as bio-recognition, specific stimulus-reactivity, and controlled degradation. This review aims to give an overview of hydrogels made up of recombinant proteins or synthetic peptides as the structural elements building the polymer network. A wide variety of hydrogels composed of protein or peptide building blocks with different origins and compositions – including β-hairpin peptides, α-helical coiled coil peptides, elastin-like peptides, silk fibroin, and resilin – have been designed to date. In this review, the structures and characteristics of these natural proteins and peptides, with each of their gelation mechanisms, and the physical, chemical, and mechanical properties as well as biocompatibility of the resulting hydrogels are described. In addition, this review discusses the potential of using protein- or peptide-based hydrogels in the field of biomedical sciences, especially tissue engineering.read more
Citations
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Novel Trends in Hydrogel Development for Biomedical Applications: A Review
TL;DR: The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popularHydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogELs.
Journal ArticleDOI
A Review on Recent Advances of Protein-Polymer Hydrogels
Peter Rivière,Yuanhan Tang,Xin Zhang,Xinyue Li,Chiyue Ma,Xiaoxiao Chu,Linlin Wang,Wenlong Xu +7 more
TL;DR: Protein-polymer hydrogels have gained significant progress in various fields, such as tissue engineering, drug delivery and encapsulation, wearable sensors, adsorption, and other applications as discussed by the authors.
Journal ArticleDOI
A review on recent advances of Protein-Polymer hydrogels
TL;DR: Protein-polymer hydrogels have gained significant progress in various fields, such as tissue engineering, drug delivery and encapsulation, wearable sensors, adsorption, and other applications as mentioned in this paper .
Journal ArticleDOI
Smart Hydrogels Meet Carbon Nanomaterials for New Frontiers in Medicine.
TL;DR: Carbon nanomaterials include diverse structures and morphologies, such as fullerenes, nano-onions, nanodots, Nanodiamonds, nanohorns, nanotubes, and graphene-based materials as mentioned in this paper.
Journal ArticleDOI
Synthetic biology as driver for the biologization of materials sciences.
O. Burgos-Morales,O. Burgos-Morales,M. Gueye,L. Lacombe,C. Nowak,C. Nowak,R. Schmachtenberg,R. Schmachtenberg,Maximilian Hörner,C. Jerez-Longres,Hasti Mohsenin,Hanna J. Wagner,Hanna J. Wagner,Wilfried Weber +13 more
TL;DR: In this article, the authors identify and review two main directions by which synthetic biology can be harnessed to provide new impulses for the biologization of the materials sciences: first, the engineering of cells to produce precursors for the subsequent synthesis of materials, and second, engineered living materials that are formed or assembled by cells or in which cells contribute specific functions while remaining an integral part of the living composite material.
References
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Journal ArticleDOI
High-resolution topographic imaging of environmentally responsive, elastin-mimetic hydrogels
Journal ArticleDOI
Self-Healing Elastin–Bioglass Hydrogels
Qiongyu Zeng,Qiongyu Zeng,Qiongyu Zeng,Malav S. Desai,Malav S. Desai,Hyo-Eon Jin,Hyo-Eon Jin,Ju Hun Lee,Ju Hun Lee,Jiang Chang,Jiang Chang,Seung-Wuk Lee,Seung-Wuk Lee +12 more
TL;DR: A novel in situ forming organic/inorganic composite hydrogel with dynamic aldimine cross-links using elastin-like polypeptides (ELP) and bioglass (BG) exhibits tunable gelling behavior and mechanical characteristics in a composition and concentration dependent manner.
Journal ArticleDOI
Superparamagnetic Gold Nanoparticles Synthesized on Protein Particle Scaffolds for Cancer Theragnosis.
Koo Chul Kwon,Eunji Jo,Young Wan Kwon,Boram Lee,Ju Hee Ryu,Eunjung Lee,Kwangmeyung Kim,Jeewon Lee +7 more
TL;DR: The SPAuNCs show excellent biocompatibility without the problem of in vivo accumulation and holds promising potential as a clinically effective agent for cancer theragnosis.
Journal ArticleDOI
Chemical synthesis of cross-linked poly(KGGVG), an elastin-like biopolymer.
TL;DR: The obtained results demonstrate that poly(KGGVG), both linear and cross-linked, may be considered very similar to tropoelastin and mature elastin, as concerns its molecular and supramolecular properties.
Journal ArticleDOI
Engineering complementary hydrophobic interactions to control β-hairpin peptide self-assembly, network branching, and hydrogel properties.
Sameer Sathaye,Huixi Zhang,Cem Sonmez,Joel P. Schneider,Christopher M. MacDermaid,Christopher D Von Bargen,Jeffery G. Saven,Darrin J. Pochan +7 more
TL;DR: Molecular dynamics simulations provide a molecular picture of interpeptide interactions within the assembly that is consistent with the branching propensity of MAX1 vs LNK1 and in agreement with experimental observations.
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