Journal ArticleDOI
Designed protein- and peptide-based hydrogels for biomedical sciences
TLDR
A review of protein-and peptide-based hydrogels can be found in this paper, where the authors discuss the potential of using protein or peptide based hydrogel in the field of biomedical sciences.Abstract:
Proteins are fundamentally the most important macromolecules for biochemical, mechanical, and structural functions in living organisms. Therefore, they provide us with diverse structural building blocks for constructing various types of biomaterials, including an important class of such materials, hydrogels. Since natural peptides and proteins are biocompatible and biodegradable, they have features advantageous for their use as the building blocks of hydrogels for biomedical applications. They display constitutional and mechanical similarities with the native extracellular matrix (ECM), and can be easily bio-functionalized via genetic and chemical engineering with features such as bio-recognition, specific stimulus-reactivity, and controlled degradation. This review aims to give an overview of hydrogels made up of recombinant proteins or synthetic peptides as the structural elements building the polymer network. A wide variety of hydrogels composed of protein or peptide building blocks with different origins and compositions – including β-hairpin peptides, α-helical coiled coil peptides, elastin-like peptides, silk fibroin, and resilin – have been designed to date. In this review, the structures and characteristics of these natural proteins and peptides, with each of their gelation mechanisms, and the physical, chemical, and mechanical properties as well as biocompatibility of the resulting hydrogels are described. In addition, this review discusses the potential of using protein- or peptide-based hydrogels in the field of biomedical sciences, especially tissue engineering.read more
Citations
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Journal ArticleDOI
Novel Trends in Hydrogel Development for Biomedical Applications: A Review
TL;DR: The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popularHydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogELs.
Journal ArticleDOI
A Review on Recent Advances of Protein-Polymer Hydrogels
Peter Rivière,Yuanhan Tang,Xin Zhang,Xinyue Li,Chiyue Ma,Xiaoxiao Chu,Linlin Wang,Wenlong Xu +7 more
TL;DR: Protein-polymer hydrogels have gained significant progress in various fields, such as tissue engineering, drug delivery and encapsulation, wearable sensors, adsorption, and other applications as discussed by the authors.
Journal ArticleDOI
A review on recent advances of Protein-Polymer hydrogels
TL;DR: Protein-polymer hydrogels have gained significant progress in various fields, such as tissue engineering, drug delivery and encapsulation, wearable sensors, adsorption, and other applications as mentioned in this paper .
Journal ArticleDOI
Smart Hydrogels Meet Carbon Nanomaterials for New Frontiers in Medicine.
TL;DR: Carbon nanomaterials include diverse structures and morphologies, such as fullerenes, nano-onions, nanodots, Nanodiamonds, nanohorns, nanotubes, and graphene-based materials as mentioned in this paper.
Journal ArticleDOI
Synthetic biology as driver for the biologization of materials sciences.
O. Burgos-Morales,O. Burgos-Morales,M. Gueye,L. Lacombe,C. Nowak,C. Nowak,R. Schmachtenberg,R. Schmachtenberg,Maximilian Hörner,C. Jerez-Longres,Hasti Mohsenin,Hanna J. Wagner,Hanna J. Wagner,Wilfried Weber +13 more
TL;DR: In this article, the authors identify and review two main directions by which synthetic biology can be harnessed to provide new impulses for the biologization of the materials sciences: first, the engineering of cells to produce precursors for the subsequent synthesis of materials, and second, engineered living materials that are formed or assembled by cells or in which cells contribute specific functions while remaining an integral part of the living composite material.
References
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Journal ArticleDOI
The effect of hydration on molecular chain mobility and the viscoelastic behavior of resilin-mimetic protein-based hydrogels.
My Y. Truong,Naba K. Dutta,Namita Roy Choudhury,Mi-Sook Kim,Christopher M. Elvin,Kate M. Nairn,Anita J. Hill +6 more
TL;DR: Rheological investigations confirm that the equilibrium-swollen crosslinked rec1-resilin hydrogel exhibits outstanding elasticity and resilience of ∼ 92%, which exceeds that of any other synthetic polymer and biopolymer hydrogels.
Journal ArticleDOI
Photoreactive Polymers Bearing a Zwitterionic Phosphorylcholine Group for Surface Modification of Biomaterials
TL;DR: Ultraviolet-visible (UV/vis) absorption spectra of these polymer solutions showed that these polymers have maximum absorption peaks at 254 and 289 nm that can be attributed to the benzophenone unit.
Journal ArticleDOI
Swelling Behavior of γ-Irradiation Cross-Linked Elastomeric Polypentapeptide-Based Hydrogels
TL;DR: Different continuities found in the phase transitions of these polymers and poly(N-isopropylacrylamide) were discussed in terms of cooperative units, and Fick's law was able to explain their initial dynamic swelling behavior.
Journal ArticleDOI
Beta Hairpin Peptide Hydrogels as an Injectable Solid Vehicle for Neurotrophic Growth Factor Delivery
Stephan Lindsey,Joseph H. Piatt,Peter Worthington,Cem Sonmez,Sameer Satheye,Joel P. Schneider,Darrin J. Pochan,Sigrid A. Langhans +7 more
TL;DR: The data suggests that MAX8 allows for greater dosage control and sustained therapeutic growth factor delivery, potentially alleviating side effects and improving the efficacy of current therapies.
Journal ArticleDOI
Effect of beta-sheet crystals on the thermal and rheological behavior of protein-based hydrogels derived from gelatin and silk fibroin.
TL;DR: The temperature-dependent elastic modulus across the G helix-coil transition is reversible, indicating that the conformational change in G can be used in stabilized G/SF hydrogels to induce thermally triggered encapsulant release.
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