Journal ArticleDOI
Designed protein- and peptide-based hydrogels for biomedical sciences
TLDR
A review of protein-and peptide-based hydrogels can be found in this paper, where the authors discuss the potential of using protein or peptide based hydrogel in the field of biomedical sciences.Abstract:
Proteins are fundamentally the most important macromolecules for biochemical, mechanical, and structural functions in living organisms. Therefore, they provide us with diverse structural building blocks for constructing various types of biomaterials, including an important class of such materials, hydrogels. Since natural peptides and proteins are biocompatible and biodegradable, they have features advantageous for their use as the building blocks of hydrogels for biomedical applications. They display constitutional and mechanical similarities with the native extracellular matrix (ECM), and can be easily bio-functionalized via genetic and chemical engineering with features such as bio-recognition, specific stimulus-reactivity, and controlled degradation. This review aims to give an overview of hydrogels made up of recombinant proteins or synthetic peptides as the structural elements building the polymer network. A wide variety of hydrogels composed of protein or peptide building blocks with different origins and compositions – including β-hairpin peptides, α-helical coiled coil peptides, elastin-like peptides, silk fibroin, and resilin – have been designed to date. In this review, the structures and characteristics of these natural proteins and peptides, with each of their gelation mechanisms, and the physical, chemical, and mechanical properties as well as biocompatibility of the resulting hydrogels are described. In addition, this review discusses the potential of using protein- or peptide-based hydrogels in the field of biomedical sciences, especially tissue engineering.read more
Citations
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Journal ArticleDOI
Novel Trends in Hydrogel Development for Biomedical Applications: A Review
TL;DR: The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popularHydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogELs.
Journal ArticleDOI
A Review on Recent Advances of Protein-Polymer Hydrogels
Peter Rivière,Yuanhan Tang,Xin Zhang,Xinyue Li,Chiyue Ma,Xiaoxiao Chu,Linlin Wang,Wenlong Xu +7 more
TL;DR: Protein-polymer hydrogels have gained significant progress in various fields, such as tissue engineering, drug delivery and encapsulation, wearable sensors, adsorption, and other applications as discussed by the authors.
Journal ArticleDOI
A review on recent advances of Protein-Polymer hydrogels
TL;DR: Protein-polymer hydrogels have gained significant progress in various fields, such as tissue engineering, drug delivery and encapsulation, wearable sensors, adsorption, and other applications as mentioned in this paper .
Journal ArticleDOI
Smart Hydrogels Meet Carbon Nanomaterials for New Frontiers in Medicine.
TL;DR: Carbon nanomaterials include diverse structures and morphologies, such as fullerenes, nano-onions, nanodots, Nanodiamonds, nanohorns, nanotubes, and graphene-based materials as mentioned in this paper.
Journal ArticleDOI
Synthetic biology as driver for the biologization of materials sciences.
O. Burgos-Morales,O. Burgos-Morales,M. Gueye,L. Lacombe,C. Nowak,C. Nowak,R. Schmachtenberg,R. Schmachtenberg,Maximilian Hörner,C. Jerez-Longres,Hasti Mohsenin,Hanna J. Wagner,Hanna J. Wagner,Wilfried Weber +13 more
TL;DR: In this article, the authors identify and review two main directions by which synthetic biology can be harnessed to provide new impulses for the biologization of the materials sciences: first, the engineering of cells to produce precursors for the subsequent synthesis of materials, and second, engineered living materials that are formed or assembled by cells or in which cells contribute specific functions while remaining an integral part of the living composite material.
References
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Journal ArticleDOI
Mussel-mimetic protein-based adhesive hydrogel.
Bum Jin Kim,Dongyeop X. Oh,Sangsik Kim,Jeong Hyun Seo,Dong Soo Hwang,Admir Masic,Dong Keun Han,Hyung Joon Cha +7 more
TL;DR: A novel protein-based hydrogel system using DOPA-containing recombinant MAP, which has higher cohesive strength and can provide sufficient gelation time for easier handling and can potentially be used as tissue adhesive and sealant for future applications.
Journal ArticleDOI
Swelling and mechanical behaviors of chemically cross-linked hydrogels of elastin-like polypeptides.
TL;DR: Swelling experiments indicate hydrogel mass decreases by 80-90% gradually over an approximate 50 degrees C temperature range, and changes in gel stiffness and loss angle with cross-linking formulation suggest a low-temperature gel structure that is nearly completely elastic, and a high-tem temperature gel structure, where ELP chains are contracted and force is transmitted through chemical cross-links as well as frictional contact between polypeptide chains.
Journal ArticleDOI
The use of injectable sonication-induced silk hydrogel for VEGF(165) and BMP-2 delivery for elevation of the maxillary sinus floor.
Wenjie Zhang,Xiuli Wang,Xiuli Wang,Shaoyi Wang,Jun Zhao,Lianyi Xu,Chao Zhu,Deliang Zeng,Jake Y. Chen,Zhiyuan Zhang,David L. Kaplan,Xinquan Jiang +11 more
TL;DR: It is indicated that silk hydrogels can be used as an injectable vehicle to deliver multiple growth factors in a minimally invasive approach to regenerate irregular bony cavities.
Journal ArticleDOI
Engineering nanoscale order into a designed protein fiber
David Papapostolou,Andrew M. Smith,Edward D. T. Atkins,Seb Oliver,Maxim G. Ryadnov,Louise C. Serpell,Derek N. Woolfson +6 more
TL;DR: It is shown that rational mutations to the original peptide designs lead to structures with a remarkable level of order on the nanoscale that mimics certain natural fibrous assemblies, a step toward rational bottom-up assembly of nanostructured fibrous biomaterials for potential applications in synthetic biology and nanobiotechnology.
Journal ArticleDOI
Engineering a highly elastic human protein-based sealant for surgical applications.
Nasim Annabi,Yi-Nan Zhang,Yi-Nan Zhang,Alexander Assmann,Ehsan Shirzaei Sani,George Cheng,Antonio D. Lassaletta,Andrea Vegh,Andrea Vegh,B Dehghani,B Dehghani,Guillermo U. Ruiz-Esparza,Guillermo U. Ruiz-Esparza,Xichi Wang,Xichi Wang,Sidhu P. Gangadharan,Anthony S. Weiss,Ali Khademhosseini +17 more
TL;DR: The engineered MeTro sealant has high potential for clinical applications because of superior adhesion and mechanical properties compared to commercially available sealants, as well as opportunity for further optimization of the degradation rate to fit desired surgical applications on different tissues.
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