Journal ArticleDOI
Designed protein- and peptide-based hydrogels for biomedical sciences
TLDR
A review of protein-and peptide-based hydrogels can be found in this paper, where the authors discuss the potential of using protein or peptide based hydrogel in the field of biomedical sciences.Abstract:
Proteins are fundamentally the most important macromolecules for biochemical, mechanical, and structural functions in living organisms. Therefore, they provide us with diverse structural building blocks for constructing various types of biomaterials, including an important class of such materials, hydrogels. Since natural peptides and proteins are biocompatible and biodegradable, they have features advantageous for their use as the building blocks of hydrogels for biomedical applications. They display constitutional and mechanical similarities with the native extracellular matrix (ECM), and can be easily bio-functionalized via genetic and chemical engineering with features such as bio-recognition, specific stimulus-reactivity, and controlled degradation. This review aims to give an overview of hydrogels made up of recombinant proteins or synthetic peptides as the structural elements building the polymer network. A wide variety of hydrogels composed of protein or peptide building blocks with different origins and compositions – including β-hairpin peptides, α-helical coiled coil peptides, elastin-like peptides, silk fibroin, and resilin – have been designed to date. In this review, the structures and characteristics of these natural proteins and peptides, with each of their gelation mechanisms, and the physical, chemical, and mechanical properties as well as biocompatibility of the resulting hydrogels are described. In addition, this review discusses the potential of using protein- or peptide-based hydrogels in the field of biomedical sciences, especially tissue engineering.read more
Citations
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Novel Trends in Hydrogel Development for Biomedical Applications: A Review
TL;DR: The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popularHydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogELs.
Journal ArticleDOI
A Review on Recent Advances of Protein-Polymer Hydrogels
Peter Rivière,Yuanhan Tang,Xin Zhang,Xinyue Li,Chiyue Ma,Xiaoxiao Chu,Linlin Wang,Wenlong Xu +7 more
TL;DR: Protein-polymer hydrogels have gained significant progress in various fields, such as tissue engineering, drug delivery and encapsulation, wearable sensors, adsorption, and other applications as discussed by the authors.
Journal ArticleDOI
A review on recent advances of Protein-Polymer hydrogels
TL;DR: Protein-polymer hydrogels have gained significant progress in various fields, such as tissue engineering, drug delivery and encapsulation, wearable sensors, adsorption, and other applications as mentioned in this paper .
Journal ArticleDOI
Smart Hydrogels Meet Carbon Nanomaterials for New Frontiers in Medicine.
TL;DR: Carbon nanomaterials include diverse structures and morphologies, such as fullerenes, nano-onions, nanodots, Nanodiamonds, nanohorns, nanotubes, and graphene-based materials as mentioned in this paper.
Journal ArticleDOI
Synthetic biology as driver for the biologization of materials sciences.
O. Burgos-Morales,O. Burgos-Morales,M. Gueye,L. Lacombe,C. Nowak,C. Nowak,R. Schmachtenberg,R. Schmachtenberg,Maximilian Hörner,C. Jerez-Longres,Hasti Mohsenin,Hanna J. Wagner,Hanna J. Wagner,Wilfried Weber +13 more
TL;DR: In this article, the authors identify and review two main directions by which synthetic biology can be harnessed to provide new impulses for the biologization of the materials sciences: first, the engineering of cells to produce precursors for the subsequent synthesis of materials, and second, engineered living materials that are formed or assembled by cells or in which cells contribute specific functions while remaining an integral part of the living composite material.
References
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Journal ArticleDOI
A Biocompatible and Biodegradable Protein Hydrogel with Green and Red Autofluorescence: Preparation, Characterization and In Vivo Biodegradation Tracking and Modeling.
Xiaoyu Ma,Xiangcheng Sun,Derek Hargrove,Jun Chen,Donghui Song,Qiuchen Dong,Xiuling Lu,Tai-Hsi Fan,Youjun Fu,Yu Lei +9 more
TL;DR: It is reported that glutaraldehyde cross-linked BSA (or HSA) forms a novel fluorescent biological hydrogel, exhibiting new green and red autofluorescence in vitro and in vivo without the use of any additional fluorescent labels.
Journal ArticleDOI
Expression, cross-linking, and characterization of recombinant chitin binding resilin.
Guokui Qin,Shaul Lapidot,Keiji Numata,Xiao Hu,Sigal Meirovitch,Mara Dekel,Itai Podoler,Oded Shoseyov,David L. Kaplan +8 more
TL;DR: The unusual elastomeric behavior of this protein suggests possible utility in biomaterials applications and little structural organization was found by these biophysical methods, suggesting structural order was not induced by the dityrosine crosslinks.
Journal ArticleDOI
Serial elastic elements in the damselfly wing: mobile vein joints contain resilin
TL;DR: The distribution of serial elastic elements in the damselfly wing is mapped and the occurrence of resilin, a rubberlike protein, in mobile joints suggests that the automatic twisting mechanism of the leading edge by aerodynamic force works not by flexibility but by the elasticity of these joints.
Journal ArticleDOI
Tentative identification of a resilin gene in Drosophila melanogaster.
TL;DR: It is suggested that gene product CG15920 is a Drosophila resilin precursor, which has an amino acid composition closely resembling that of resilins from various insect species, and it has an N-terminal signal peptide sequence indicating that it is an extracellular protein.
Journal ArticleDOI
Forced protein unfolding leads to highly elastic and tough protein hydrogels.
Jie Fang,Alexander Mehlich,Nobuyasu Koga,Jiqing Huang,Rie Koga,Xiaoye Gao,Chunguang Hu,Chi Jin,Matthias Rief,Juergen Kast,David Baker,Hongbin Li +11 more
TL;DR: The engineering of a chemically crosslinked, highly elastic and tough protein hydrogel using a mechanically extremely labile, de novo designed protein that assumes the classical ferredoxin-like fold structure is reported.
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