Desmosome structure, composition and function
David R. Garrod,Martyn Chidgey +1 more
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TLDR
The structure, composition and function of desmosomes are considered, and their role in embryonic development and disease is considered.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2008-03-01 and is currently open access. It has received 520 citations till now.read more
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TGF-beta-induced epithelial to mesenchymal transition.
TL;DR: The induction of EMT in response to TGF-β is discussed, and the underlying signaling and transcription mechanisms are focused on.
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Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
Nicola Aceto,Aditya Bardia,David T. Miyamoto,Maria C. Donaldson,Ben S. Wittner,Joel A. Spencer,Min Yu,Adam Pely,Amanda Engstrom,Huili Zhu,Brian W. Brannigan,Ravi Kapur,Shannon L. Stott,Toshi Shioda,Sridhar Ramaswamy,David T. Ting,Charles P. Lin,Mehmet Toner,Daniel A. Haber,Daniel A. Haber,Shyamala Maheswaran +20 more
TL;DR: Using mouse models with tagged mammary tumors, it is demonstrated that CTC clusters arise from oligoclonal tumor cell groupings and not from intravascular aggregation events, and though rare in the circulation, they greatly contribute to the metastatic spread of cancer.
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Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components
Dulantha Ulluwishewa,Rachel C. Anderson,Warren C. McNabb,Warren C. McNabb,Paul J. Moughan,Jerry M. Wells,Nicole C. Roy +6 more
TL;DR: The human intestinal epithelium is formed by a single layer of epithelial cells that separates the intestinal lumen from the underlying lamina propria, which is sealed by tight junctions (TJ), which regulate the permeability of the intestinal barrier.
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Adherens junctions: from molecules to morphogenesis
Tony J. C. Harris,Ulrich Tepass +1 more
TL;DR: Recent work has greatly advanced understanding of the molecular organization of AJs and how cadherin–catenin complexes engage actin, microtubules and the endocytic machinery, and gained important insights into the molecular mechanisms of tissue morphogenesis.
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Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis.
TL;DR: To provide a stable environmental barrier, the epidermis requires an integrated network of cytoskeletal elements and cellular junctions that regulate epidermal polarization, signalling and barrier formation.
References
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PEST sequences and regulation by proteolysis
TL;DR: Recent experimental support for the hypothesis that polypeptide sequences enriched in proline, glutamic acid, serine, and threonine target proteins for rapid destruction is provided with a number of papers providing strong evidence that PEST regions serve as proteolytic signals.
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Cadherins in development: cell adhesion, sorting, and tissue morphogenesis
TL;DR: How different members of the cadherin family act in different developmental contexts is examined, and the mechanisms involved are discussed.
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Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease).
Godfrina McKoy,Nikos Protonotarios,Andrew H. Crosby,Adalena Tsatsopoulou,Aris Anastasakis,Aman S. Coonar,Mark Norman,C Baboonian,Steve Jeffery,William J. McKenna +9 more
TL;DR: The finding of a deletion in plakoglobin in ARVC suggests that the proteins involved in cell-cell adhesion play an important part in maintaining myocyte integrity, and when junctions are disrupted, cell death, and fibrofatty replacement occur.
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Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome.
Stephane Chavanas,Christine Bodemer,Ariane Rochat,D. Hamel-Teillac,M Ali,Alan D. Irvine,Jean-Louis Bonafé,John D Wilkinson,Alain Taieb,Yann Barrandon,John I. Harper,Y. De Prost,Alain Hovnanian +12 more
TL;DR: A critical role of SPINK5 in epidermal barrier function and immunity is disclosed, and a new pathway for high serum IgE levels and atopic manifestations is suggested.