Development and Maintenance of Regulatory T cells
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TLDR
Understanding how epigenetic alterations and Foxp3 expression coordinately control Treg-cell-specific gene regulation will enable better control of immune responses by targeting the generation and maintenance of Treg cells.About:
This article is published in Immunity.The article was published on 2013-03-21 and is currently open access. It has received 632 citations till now. The article focuses on the topics: FOXP3 & Regulation of gene expression.read more
Citations
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Journal ArticleDOI
Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells
Cara N. Skon,June-Yong Lee,Kristin G. Anderson,David Masopust,Kristin A. Hogquist,Stephen C. Jameson +5 more
TL;DR: It is found that regulation of KLF2 and S1P1 provides a switch that dictates whether CD8+ T cells commit to recirculating or tissue-resident memory populations.
Journal ArticleDOI
CD28 Costimulation: From Mechanism to Therapy
TL;DR: The roles that CD28 and its family members play in human disease and the clinical efficacy of drugs that block CD28 ligands are reviewed and outline the complex receptor-ligand interactions among CD28 family members.
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The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells
Ajithkumar Vasanthakumar,Kazuyo Moro,Annie Xin,Yang Liao,Renee Gloury,Shimpei Kawamoto,Sidonia Fagarasan,Lisa A. Mielke,Shoukat Afshar-Sterle,Seth L. Masters,Susumu Nakae,Hirohisa Saito,John M. Wentworth,Peng-Peng Li,Wei Liao,Warren J. Leonard,Gordon K. Smyth,Wei Shi,Stephen L. Nutt,Shigeo Koyasu,Axel Kallies +20 more
TL;DR: It is shown that interleukin 33 (IL-33) signaling through the IL-33 receptor ST2 and myeloid differentiation factor MyD88 is essential for development and maintenance of VAT-Treg cells and sustains their transcriptional signature.
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Regulatory T cells in autoimmune disease.
TL;DR: How the instability and plasticity of Treg cells can contribute to the breakdown of tolerance and lead to autoimmune disease is described.
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The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome
Sara Omenetti,Theresa T. Pizarro +1 more
TL;DR: Dysbiosis of the gut microbiome may not solely represent a consequence of gut inflammation, but rather shape the Treg/Th17 commitment and influence susceptibility to inflammatory bowel disease.
References
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Journal ArticleDOI
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
TL;DR: Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells and retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+.
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Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells
TL;DR: It is reported that the forkhead transcription factor Foxp3 is specifically expressed in CD4+CD25+ regulatory T cells and is required for their development and function and ectopic expression ofFoxp3 confers suppressor function on peripheral CD4-CD25− T cells.
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Regulatory T Cells and Immune Tolerance
TL;DR: The cellular and molecular basis of Treg development and function is revealed and dysregulation of T Regs in immunological disease is implicates.
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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.
Craig L. Bennett,Jacinda R. Christie,Fred Ramsdell,Mary E. Brunkow,Polly J. Ferguson,Luke Whitesell,Thaddeus E. Kelly,Frank T. Saulsbury,Phillip F. Chance,Hans D. Ochs +9 more
TL;DR: Genetic evidence is presented that different mutations of the human gene FOXP3, the ortholog of the gene mutated in scurfy mice (Foxp3), causes IPEX syndrome.
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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
Mary E. Brunkow,Jeffery Ew,Hjerrild Ka,Bryan W. Paeper,L B Clark,Yasayko Sa,John E. Wilkinson,David J. Galas,Steven F. Ziegler,Fred Ramsdell +9 more
TL;DR: Genetic complementation demonstrates that the protein product of Foxp3, scurfin, is essential for normal immune homeostasis.