Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee
Roy D. Altman,E. Asch,Daniel Bloch,Giles G. Bole,David G. Borenstein,Kenneth D. Brandt,Wallace C. Christy,Cooke Td,Robert A. Greenwald,Marc C. Hochberg,David S. Howell,David L. Kaplan,William J. Koopman,Selden Longley,Henry J. Mankin,Dennis J. McShane,Thomas A. Medsger,Robert F. Meenan,William M. Mikkelsen,Roland W. Moskowitz,William A. Murphy,B. Rothschild,Mark R. Segal,Leon Sokoloff,Frederick Wolfe +24 more
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TLDR
Variables from the medical history, physical examination, laboratory tests, and radiographs were used to develop sets of criteria that serve different investigative purposes and these proposed criteria utilize classification trees, or algorithms.Abstract:
For the purposes of classification, it should be specified whether osteoarthritis (OA) of the knee is of unknown origin (idiopathic, primary) or is related to a known medical condition or event (secondary). Clinical criteria for the classification of idiopathic OA of the knee were developed through a multicenter study group. Comparison diagnoses included rheumatoid arthritis and other painful conditions of the knee, exclusive of referred or para-articular pain. Variables from the medical history, physical examination, laboratory tests, and radiographs were used to develop sets of criteria that serve different investigative purposes. In contrast to prior criteria, these proposed criteria utilize classification trees, or algorithms.read more
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Evidence of effectiveness of herbal medicinal products in the treatment of arthritis: HERBAL MEDICINAL PRODUCTS FOR RHEUMATOID ARTHRITIS
Melainie Cameron,Joel Gagnier,Christine V. Little,Tessa J. Parsons,Anette Blümle,Sigrun Chrubasik +5 more
TL;DR: This study searched electronic databases to June 2007 and included randomized controlled trials that compared HMPs with inert (placebo) or active controls in patients with rheumatoid arthritis.
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The Risk of Major NSAID Toxicity with Celecoxib, Ibuprofen, or Naproxen: A Secondary Analysis of the PRECISION Trial.
Daniel H. Solomon,M. Elaine Husni,Peter Libby,Neville D. Yeomans,Neville D. Yeomans,A. Michael Lincoff,Thomas F. Lϋscher,Venu Menon,Danielle M. Brennan,Lisa Wisniewski,Steven E. Nissen,Jeffrey S. Borer +11 more
TL;DR: A post hoc analysis of a double-blind, randomized, controlled, multicenter trial enrolling 24,081 patients with osteoarthritis or rheumatoid arthritis at moderate or high cardiovascular risk found that patients using naproxen or ibuprofen experienced significantly higher risk of major toxicity than those using celecoxib.
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Expression and Tissue Localization of Membrane-Types 1, 2, and 3 Matrix Metalloproteinases in Rheumatoid Synovium
Hajime Yamanaka,Ken ichi Makino,Masayuki Takizawa,Hiroyuki Nakamura,Noboru Fujimoto,Hideshige Moriya,Ryoichi Nemori,Hiroshi Sato,Motoharu Seiki,Yasunori Okada +9 more
TL;DR: It is demonstrated that MT1-MMP plays an important role in the activation of proMMP-2 in the rheumatoid synovial lining cell layer, and suggest that its activity may be involved in the cartilage destruction of r heumatoid arthritis.
Journal ArticleDOI
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
Yoshinaga Ito,Motomu Hashimoto,Keiji Hirota,Naganari Ohkura,Hiromasa Morikawa,Hiroyoshi Nishikawa,Atsushi Tanaka,Moritoshi Furu,Hiromu Ito,Takao Fujii,Takashi Nomura,Sayuri Yamazaki,Akimichi Morita,Dario A. A. Vignali,Dario A. A. Vignali,John W. Kappler,Shuichi Matsuda,Tsuneyo Mimori,Noriko Sakaguchi,Shimon Sakaguchi,Shimon Sakaguchi +20 more
TL;DR: T cells that mediate autoimmune diseases such as rheumatoid arthritis are difficult to characterize because they are likely to be deleted or inactivated in the thymus if the self antigens they recognize are ubiquitously expressed, but one way to obtain and analyze these autoimmune T cells is to alter T cell receptor (TCR) signaling in developing T cells to change their sensitivity toThymic negative selection, thereby allowing their thymic production.
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Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: a randomized, double-blind, dose-escalation, placebo-controlled study
TL;DR: Tanezumab was safe and generally well tolerated and may improve pain symptoms in Japanese patients with moderate to severe osteoarthritis of the knee.
References
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Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
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Journal Article
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