Diabetes Mellitus and Prevention of Late Myocardial Infarction After Coronary Stenting in the Randomized Dual Antiplatelet Therapy Study
Ian T. Meredith,Jean Francois Tanguay,Dean J. Kereiakes,Donald E. Cutlip,Robert W. Yeh,Kirk N. Garratt,David P. Lee,P. Gabriel Steg,W. Douglas Weaver,David R. Holmes,Ralph G. Brindis,Jaroslaw Trebacz,Joseph M. Massaro,Wen Hua Hsieh,Laura Mauri +14 more
TLDR
In patients with DM, continued thienopyridine beyond 1 year after coronary stenting is associated with reduced risk of MI, although this benefit is attenuated in comparison with patients without DM.Abstract:
Background—Patients with diabetes mellitus (DM) are at high risk for recurrent ischemic events after coronary stenting. We assessed the effects of continued thienopyridine among patients with DM participating in the Dual Antiplatelet Therapy (DAPT) Study as a prespecified analysis. Methods and Results—After coronary stent placement and 12 months treatment with open-label thienopyridine plus aspirin, 11 648 patients free of ischemic or bleeding events and who were medication compliant were randomly assigned to continued thienopyridine or placebo, in addition to aspirin, for 18 more months. After randomization, patients with DM (n=3391), in comparison with patients without DM (n=8257), had increased composite outcome of death, myocardial infarction (MI), or stroke (6.8% versus 4.3%, P<0.001), increased death (2.5% versus 1.4%, P<0.001), and MI (4.2% versus 2.6%, P<0.001). Among patients with DM, in a comparison of continued thienopyridine versus placebo, rates of stent thrombosis were 0.5% versus 1.1%, P=0....read more
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2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS).
Marco Valgimigli,Héctor Bueno,Robert A. Byrne,Jean-Philippe Collet,Francesco Costa,Anders Jeppsson,Peter Jüni,Adnan Kastrati,Philippe Kolh,Laura Mauri,Gilles Montalescot,Franz-Josef Neumann,Mate Petricevic,Marco Roffi,Philippe Gabriel Steg,Stephan Windecker,José Luis Zamorano,Glenn N. Levine,Lina Badimon,Pascal Vranckx,Stefan Agewall,Felicita Andreotti,Elliott M. Antman,Emanuele Barbato,Jean-Pierre Bassand,Raffaele Bugiardini,Mustafa Cikirikcioglu,Thomas Cuisset,Michele De Bonis,Victora Delgado,Donna Fitzsimons,Oliver Gaemperli,Nazzareno Galiè,Martine Gilard,Christian W. Hamm,Borja Ibanez,Bernard Iung,Stefan James,Juhani Knuuti,Ulf Landmesser,Christophe Leclercq,Maddalena Lettino,Gregory Y.H. Lip,Massimo F Piepoli,Luc Pierard,Markus Schwerzmann,Udo Sechtem,Iain A. Simpson,Miguel Sousa Uva,Eugenio Stabile,Robert F. Storey,Michal Tendera,Frans Van de Werf,Freek W.A. Verheugt,Victor Aboyans,Antonio Coca,I M Coman,Veronica Dean,Victoria Delgado,Gerhard Hindricks,Hugo A. Katus,Patrizio Lancellotti,Theresa McDonagh,Piotr Ponikowski,Dimitrios J. Richter,Evgeny Shlyakhto,Franz Xaver Roithinger,Farid Aliyev,Valeriy Stelmashok,Walter Desmet,Arman Postadzhiyan,Georgios P Georghiou,Zuzana Motovska,Erik Lerkevang Grove,Toomas Marandi,Tuomas Kiviniemi,Sasko Kedev,Steffen Massberg,Dimitrios Alexopoulos,Róbert Gábor Kiss,Ingibjorg Jona Gudmundsdottir,Eugene P. McFadden,Eli I. Lev,Leonardo De Luca,Akhmetzhan Sugraliyev,Edmond Haliti,Erkin M. Mirrakhimov,Gustavs Latkovskis,Birute Petrauskiene,Steve Huijnen,Caroline Jane Magri,Rhizlan Cherradi,Jurriën M. ten Berg,Jan Eritsland,Andrzej Budaj,Carlos Aguiar,Dmitry Duplyakov,Marco Zavatta,Nebojsa M Antonijevic,Zlatko Fras,Antonio Tello Montoliu,Christoph Varenhorst,Dimitri Tsakiris,Faouzi Addad,Sinan Aydogdu,Alexander Parkhomenko,Tim Kinnaird +106 more
TL;DR: The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) developed in collaboration with EACTS is described in this paper.
Journal ArticleDOI
2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS
Marco Valgimigli,Héctor Bueno,Robert A. Byrne,Jean-Philippe Collet,Francesco Costa,Anders Jeppsson,Peter Jüni,Adnan Kastrati,Philippe Kolh,Laura Mauri,Gilles Montalescot,Franz-Josef Neumann,Mate Petricevic,Marco Roffi,Philippe Gabriel Steg,Stephan Windecker,José Luis Zamorano,Glenn N. Levine,Lina Badimon,Pascal Vranckx,Stefan Agewall,Felicita Andreotti,Elliott M. Antman,Emanuele Barbato,Jean-Pierre Bassand,Raffaele Bugiardini,Mustafa Cikirikcioglu,Thomas Cuisset,Michele De Bonis,Victora Delgado,Donna Fitzsimons,Oliver Gaemperli,Nazzareno Galiè,Martine Gilard,Christian W. Hamm,Borja Ibanez,Bernard Iung,Stefan James,Juhani Knuuti,Ulf Landmesser,Christophe Leclercq,Maddalena Lettino,Gregory Y.H. Lip,Massimo F Piepoli,Luc Pierard,Markus Schwerzmann,Udo Sechtem,Iain A. Simpson,Miguel Sousa Uva,Eugenio Stabile,Robert F. Storey,Michal Tendera,Frans Van de Werf,Freek W.A. Verheugt,Victor Aboyans +54 more
Journal ArticleDOI
2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS.
Marco Valgimigli,Héctor Bueno,Robert A. Byrne,Jean-Philippe Collet,Francesco Costa,Anders Jeppsson,Peter Jüni,Adnan Kastrati,Philippe Kolh,Laura Mauri,Gilles Montalescot,Franz-Josef Neumann,Mate Peticevic,Marco Roffi,Philippe Gabriel Steg,Stephan Windecker,José Luis Zamorano +16 more
TL;DR: Authors/Task Force Members: Marco Valgimigli* (Chairperson) (Switzerland), Héctor Bueno (Spain), Robert A. Byrne (Germany), Jean-Philippe Collet (France), Francesco Costa (Italy), Anders Jeppsson (Sweden), Peter Jüni (Canada), Adnan Kastrati ( Germany), Philippe Kolh (Belgium), Laura Mauri (USA), Gilles Montalescot (France).
Journal ArticleDOI
Ticagrelor in Patients with Stable Coronary Disease and Diabetes
P. Gabriel Steg,Deepak L. Bhatt,Tabassome Simon,Kim Fox,Shamir R. Mehta,Robert A. Harrington,Claes Held,Marielle Andersson,Anders Himmelmann,Wilhelm Ridderstråle,Maria Leonsson-Zachrisson,Yuyin Liu,Grzegorz Opolski,D A Zateyshchikov,Junbo Ge,Jose C. Nicolau,Ramón Corbalán,Jan H. Cornel,Petr Widimský,Lawrence A. Leiter +19 more
TL;DR: In patients with stable coronary artery disease and diabetes without a history of myocardial infarction or stroke, patients who received ticagrelor plus aspirin had a lower incidence of ischemic cardiovascular events but a higher incidence of major bleeding than those who received placebo plus aspirin.
Journal ArticleDOI
Lesion Complexity and Outcomes of Extended Dual Antiplatelet Therapy After Percutaneous Coronary Intervention
Robert W. Yeh,Dean J. Kereiakes,P. Gabriel Steg,Donald E. Cutlip,Kevin Croce,Joseph M. Massaro,Laura Mauri,Dapt Study Investigators +7 more
TL;DR: In this article, the authors assessed the effect of 30 months versus 12 months of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) based on the presence or absence of anatomically complex target lesions.
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