Direction selectivity in retinal bipolar cell axon terminals.
Akihiro Matsumoto,Weaam Agbariah,Stella Solveig Nolte,Rawan Andrawos,Hadara Levi,Shai Sabbah,Keisuke Yonehara +6 more
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TLDR
In this article, the authors used two-photon glutamate imaging to measure synaptic release and reveal that direction selectivity along all four directions arises earlier than expected at bipolar cell outputs.About:
This article is published in Neuron.The article was published on 2021-09-15 and is currently open access. It has received 14 citations till now. The article focuses on the topics: Axon terminal & Retina.read more
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Journal ArticleDOI
Direction Selectivity of TmY Neurites in Drosophila
Posted ContentDOI
Asymmetric retinal direction tuning predicts optokinetic eye movements across stimulus conditions
TL;DR: In this article , the authors demonstrate that motion encoding in vertically-tuned oDSGCs is contrast-sensitive and asymmetric for ODSGC types that prefer opposite directions.
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New insights into retinal circuits through EM connectomics: what we have learnt and what remains to be learned
TL;DR: The retinal neural circuit is intricately wired for efficient processing of visual signals and is well-supported by the specialized connections between retinal neurons at both the functional and ultrastructural levels as mentioned in this paper .
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Emerging computational motifs: Lessons from the retina
TL;DR: A review of recent advances in the understanding of direction selectivity circuits in the retina can be found in this article , where it is shown that the retina utilizes complicated and sophisticated mechanisms in which excitatory and inhibitory pathways are involved in the efficient encoding of motion information.
References
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Chris Fraley,Adrian E. Raftery +1 more
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Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics.
Karthik Shekhar,Sylvain W. Lapan,Sylvain W. Lapan,Irene E. Whitney,Nicholas M. Tran,Evan Z. Macosko,Evan Z. Macosko,Monika S. Kowalczyk,Xian Adiconis,Joshua Z. Levin,James Nemesh,James Nemesh,Melissa Goldman,Melissa Goldman,Steven A. McCarroll,Steven A. McCarroll,Constance L. Cepko,Constance L. Cepko,Aviv Regev,Aviv Regev,Aviv Regev,Joshua R. Sanes +21 more
TL;DR: This work provides a systematic methodology for achieving comprehensive molecular classification of neurons, identifies novel neuronal types, and uncovers transcriptional differences that distinguish types within a class.
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Connectomic reconstruction of the inner plexiform layer in the mouse retina
Moritz Helmstaedter,Kevin L. Briggman,Srinivas C. Turaga,Srinivas C. Turaga,Viren Jain,Viren Jain,H. Sebastian Seung,Winfried Denk +7 more
TL;DR: Circuit motifs that emerge from the data indicate a functional mechanism for a known cellular response in a ganglion cell that detects localized motion, and predict that another ganglions cell is motion sensitive.
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An optimized fluorescent probe for visualizing glutamate neurotransmission
Jonathan S. Marvin,Bart G. Borghuis,Bart G. Borghuis,Lin Tian,Lin Tian,Joseph Cichon,Mark T. Harnett,Jasper Akerboom,Andrew Gordus,Sabine L. Renninger,Tsai Wen Chen,Cornelia I. Bargmann,Michael B. Orger,Eric R. Schreiter,Jonathan B. Demb,Wen-Biao Gan,S. Andrew Hires,Loren L. Looger +17 more
TL;DR: An intensity-based glutamate-sensing fluorescent reporter with signal-to-noise ratio and kinetics appropriate for in vivo imaging is described and its utility for visualizing glutamate release by neurons and astrocytes in increasingly intact neurological systems is validated.