Direction selectivity in retinal bipolar cell axon terminals.
Akihiro Matsumoto,Weaam Agbariah,Stella Solveig Nolte,Rawan Andrawos,Hadara Levi,Shai Sabbah,Keisuke Yonehara +6 more
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TLDR
In this article, the authors used two-photon glutamate imaging to measure synaptic release and reveal that direction selectivity along all four directions arises earlier than expected at bipolar cell outputs.About:
This article is published in Neuron.The article was published on 2021-09-15 and is currently open access. It has received 14 citations till now. The article focuses on the topics: Axon terminal & Retina.read more
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Origins of direction selectivity in the primate retina
TL;DR: In this article , the authors combined functional recordings of light-evoked responses and connectomic reconstruction to identify diverse direction-selective cell types in the macaque monkey retina with distinctive physiological properties and synaptic motifs.
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Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina
Sarah Strauss,Maria M. Korympidou,Yanli Ran,Katrin Franke,Timm Schubert,Tom Baden,Philipp Berens,Thomas Euler,Anna Vlasits +8 more
TL;DR: In this article , the authors studied the representation of motion in mouse retinal bipolar cells and found that some bipolar cells are radially direction selective, preferring the origin of small object motion trajectories.
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Distinct inhibitory pathways control velocity and directional tuning in the mouse retina
TL;DR: In this article , the authors investigated two circuits responsible for encoding different aspects of image motion: ON and ON-OFF direction-selective ganglion cells (DSGCs) and showed that distinct inhibitory pathways independently control tuning for motion velocity and motion direction in these two cell types.
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Classical center-surround receptive fields facilitate novel object detection in retinal bipolar cells
TL;DR: In this paper , the authors found that bipolar glutamate release emphasizes objects that emerge in the receptive field (RF) during continuous motion, and that the alteration in signal dynamics induced by novel objects was more pronounced than edge enhancement.
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Diurnal changes in the efficiency of information transmission at a sensory synapse
TL;DR: In this paper , the authors investigated how neuromodulation alters the amount of information transmitted through the circuit and demonstrated that contrast sensitivity peaks in the afternoon accompanied by a four-fold increase in the average Shannon information transmitted from an active zone.
References
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A Retinal Circuit That Computes Object Motion
TL;DR: A quantitative model of these circuit elements and their interactions explains how an important visual computation is accomplished by retinal neurons and synapses.
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Species-specific wiring for direction selectivity in the mammalian retina
TL;DR: A detailed connectomic reconstruction of SAC circuitry in mouse retina is presented and two previously unknown features of synapse distributions along SAC dendrite are described: input and output synapses are segregated, with inputs restricted to proximal dendrites; and the distribution of inhibitory inputs is fundamentally different from that observed in rabbit retina.
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Submillisecond Kinetics of Glutamate Release from a Sensory Synapse
TL;DR: Bipolar cell synaptic ribbons are remarkably versatile signal transducers, capable of transmitting rapidly changing sensory input, as well as sustained stimuli, due to their large pool of releasable vesicles.
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Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno‐associated virus capsid and promoter
Therese Cronin,Therese Cronin,Luk H. Vandenberghe,Luk H. Vandenberghe,Péter Hantz,Josephine Jüttner,Andreas Reimann,Ágota Kacsó,Rachel M. Huckfeldt,Volker Busskamp,Volker Busskamp,Hubertus Kohler,Pamela Lagali,Pamela Lagali,Botond Roska,Jean Bennett +15 more
TL;DR: The synthetic AAV capsid and promoter described here achieves high level of optogenetic transgene expression in ON‐bipolar cells, which evokes high‐frequency spiking responses in ganglion cells of previously blind, rd1, mice.
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Target cell-specific modulation of transmitter release at terminals from a single axon
TL;DR: It is concluded that the pharmacological and physiological properties of presynaptic terminals are determined, at least in part, by the target cells.