Distribution and location of genetic effects for dairy traits
John B. Cole,Paul M. VanRaden,Jeffrey R. O'Connell,C.P. Van Tassell,Tad S. Sonstegard,Robert D. Schnabel,Jeremy F. Taylor,G.R. Wiggans +7 more
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TLDR
A high-density scan using 38,416 single nucleotide polymorphism markers for 5,285 bulls confirmed 2 previously known major genes on Bos taurus autosomes (BTA) 6 and 14 but revealed few other large effects as discussed by the authors.About:
This article is published in Journal of Dairy Science.The article was published on 2009-06-01 and is currently open access. It has received 224 citations till now. The article focuses on the topics: Quantitative trait locus & Allele.read more
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Genomic analysis of cow mortality and milk production using a threshold-linear model
TL;DR: Investigation of genomic evaluation for cow mortality and milk production using a single-step methodology found the existence of a common region on Bos taurus autosome 14 affecting both traits may indicate a major gene with a pleiotropic effect on milk and mortality.
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Genotype by environment interactions on culling rates and 305-day milk yield of Holstein cows in 3 US regions.
TL;DR: High correlations of top SNP marker effects on culling reasons between the US regions and between large and small herds suggest that major markers can be useful for selection in different environments.
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Prediction of genomic breeding values for dairy traits in Italian Brown and Simmental bulls using a principal component approach
Maria Annunziata Pintus,Giustino Gaspa,Ezequiel L. Nicolazzi,D. Vicario,Attilio Rossoni,Paolo Ajmone-Marsan,Alessandro Nardone,Corrado Dimauro,Nicolò Pietro Paolo Macciotta +8 more
TL;DR: The principal component analysis method allowed for a reduction of about 90% in the number of independent variables when predicting direct genomic values, with a substantial decrease in calculation time and without loss of accuracy.
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Genomic Regions Associated With Gestation Length Detected Using Whole-Genome Sequence Data Differ Between Dairy and Beef Cattle.
TL;DR: Putative quantitative trait loci (QTL) regions associated with gestation length were detected in all breeds but significant associations were only detected in the HF population and in the across-breed analysis of all 22,566 sires.
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Modeling heterogeneous (co)variances from adjacent-SNP groups improves genomic prediction for milk protein composition traits
Grum Gebreyesus,Grum Gebreyesus,Mogens Sandø Lund,Bart Buitenhuis,Henk Bovenhuis,Nina Aagaard Poulsen,Luc G. Janss +6 more
TL;DR: Substantial improvement in prediction reliability was possible for most of the traits related to milk protein composition using the novel BayesAS models.
References
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Book
Introduction to quantitative genetics
TL;DR: The genetic constitution of a population: Hardy-Weinberg equilibrium and changes in gene frequency: migration mutation, changes of variance, and heritability are studied.
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Prediction of Total Genetic Value Using Genome-Wide Dense Marker Maps
TL;DR: It was concluded that selection on genetic values predicted from markers could substantially increase the rate of genetic gain in animals and plants, especially if combined with reproductive techniques to shorten the generation interval.
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Efficient Methods to Compute Genomic Predictions
TL;DR: Efficient methods for processing genomic data were developed to increase reliability of estimated breeding values and to estimate thousands of marker effects simultaneously, and a blend of first- and second-order Jacobi iteration using 2 separate relaxation factors converged well for allele frequencies and effects.
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Invited review: reliability of genomic predictions for North American Holstein bulls.
Paul M. VanRaden,C.P. Van Tassell,G.R. Wiggans,Tad S. Sonstegard,Robert D. Schnabel,Jeremy F. Taylor,Flavio S Schenkel +6 more
TL;DR: Genotypes for 38,416 markers and August 2003 genetic evaluations for 3,576 Holstein bulls born before 1999 were used to predict January 2008 daughter deviations and genomic prediction improves reliability by tracing the inheritance of genes even with small effects.