Distribution and location of genetic effects for dairy traits
John B. Cole,Paul M. VanRaden,Jeffrey R. O'Connell,C.P. Van Tassell,Tad S. Sonstegard,Robert D. Schnabel,Jeremy F. Taylor,G.R. Wiggans +7 more
TLDR
A high-density scan using 38,416 single nucleotide polymorphism markers for 5,285 bulls confirmed 2 previously known major genes on Bos taurus autosomes (BTA) 6 and 14 but revealed few other large effects as discussed by the authors.About:
This article is published in Journal of Dairy Science.The article was published on 2009-06-01 and is currently open access. It has received 224 citations till now. The article focuses on the topics: Quantitative trait locus & Allele.read more
Citations
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Invited review: reliability of genomic predictions for North American Holstein bulls.
Paul M. VanRaden,C.P. Van Tassell,G.R. Wiggans,Tad S. Sonstegard,Robert D. Schnabel,Jeremy F. Taylor,Flavio S Schenkel +6 more
TL;DR: Genotypes for 38,416 markers and August 2003 genetic evaluations for 3,576 Holstein bulls born before 1999 were used to predict January 2008 daughter deviations and genomic prediction improves reliability by tracing the inheritance of genes even with small effects.
Journal ArticleDOI
Hot topic: a unified approach to utilize phenotypic, full pedigree, and genomic information for genetic evaluation of Holstein final score.
TL;DR: A national single-step genetic evaluation with the pedigree relationship matrix augmented with genomic information provided genomic predictions with accuracy and bias comparable to multiple-step procedures and could account for any population or data structure.
Journal ArticleDOI
Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle
Hans D. Daetwyler,Aurélien Capitan,Hubert Pausch,Paul Stothard,Rianne van Binsbergen,R.F. Brøndum,Xiaoping Liao,Anis Djari,Sabrina Rodriguez,Cécile Grohs,Diane Esquerre,Olivier Bouchez,Marie-Noelle Rossignol,Christophe Klopp,Dominique Rocha,Sébastien Fritz,André Eggen,Phil J. Bowman,David Coote,Amanda J. Chamberlain,Charlotte Anderson,Curt P VanTassell,Ina Hulsegge,Michael E. Goddard,Bernt Guldbrandtsen,M.S. Lund,Roel F. Veerkamp,Didier Boichard,Ruedi Fries,Ben J. Hayes +29 more
TL;DR: The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls.
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The QTN Program and the Alleles That Matter for Evolution: All That’s Gold Does Not Glitter
TL;DR: It is argued that neither theory nor data justify a view of readily discoverable large‐effect alleles as the primary molecular substrates for evolution, and that evolution often acts via large numbers of small‐effect polygenes, individually undetectable.
Journal ArticleDOI
Computing procedures for genetic evaluation including phenotypic, full pedigree, and genomic information
TL;DR: The proposed methodology may allow the upgrading of an existing evaluation to incorporate the genomic information when the information attributable to genomics can be expressed as modifications to the numerator relationship matrix.
References
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Birth weight as a predictor of calving ease and perinatal mortality in Holstein cattle.
J.M. Johanson,P.J. Berger +1 more
TL;DR: The objective of this research was to determine the effect of birth weight on perinatal mortality (PM) and dystocia (unassisted or assisted) from the Iowa State University research dairy farm in Ankeny.
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Quantitative trait loci mapping in dairy cattle: review and meta-analysis.
TL;DR: An extensive review of public domain information on dairy cattle quantitative trait loci (QTL) revealed a number of consensus regions, the most striking being two distinct regions affecting milk yield on chromosome 6 at 49 cM and 87 cM explaining 4.2 and 3.6 percent of the genetic variance of milk yield.
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Dystocia and stillbirth in cattle — A review of causes, relations and implications
TL;DR: Research into calving difficulty (dystocia) and stillbirth in both dairy and beef cattle, as reported during the last two decades, is reviewed with emphasis on causes and effects.
Journal ArticleDOI
Detection of quantitative trait loci affecting milk production, health, and reproductive traits in Holstein cattle.
Melissa S. Ashwell,D. W. Heyen,Tad S. Sonstegard,C.P. Van Tassell,Yang Da,Paul M. VanRaden,M. Ron,Joel Ira Weller,Harris A. Lewin +8 more
TL;DR: Within-family analysis detected putative QTL associated with pregnancy rate on six chromosomes, with the effect on chromosome 18 being the most significant statistically.
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Whole genome linkage disequilibrium maps in cattle
Stephanie D. McKay,Robert D. Schnabel,Brenda M. Murdoch,Lakshmi K. Matukumalli,Lakshmi K. Matukumalli,Jan Aerts,Wouter Coppieters,Denny Crews,Denny Crews,Emmanuel Dias Neto,Clare A. Gill,Chuan Gao,Hideyuki Mannen,Paul Stothard,Zhiquan Wang,Curt P. Van Tassell,John L. Williams,Jeremy F. Taylor,Stephen S. Moore +18 more
TL;DR: The findings suggest that 30,000–50,000 loci will be needed to conduct whole genome association studies in cattle, based on a much larger sample of marker loci and across eight breeds of cattle.