Distribution and location of genetic effects for dairy traits
John B. Cole,Paul M. VanRaden,Jeffrey R. O'Connell,C.P. Van Tassell,Tad S. Sonstegard,Robert D. Schnabel,Jeremy F. Taylor,G.R. Wiggans +7 more
TLDR
A high-density scan using 38,416 single nucleotide polymorphism markers for 5,285 bulls confirmed 2 previously known major genes on Bos taurus autosomes (BTA) 6 and 14 but revealed few other large effects as discussed by the authors.About:
This article is published in Journal of Dairy Science.The article was published on 2009-06-01 and is currently open access. It has received 224 citations till now. The article focuses on the topics: Quantitative trait locus & Allele.read more
Citations
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Invited review: reliability of genomic predictions for North American Holstein bulls.
Paul M. VanRaden,C.P. Van Tassell,G.R. Wiggans,Tad S. Sonstegard,Robert D. Schnabel,Jeremy F. Taylor,Flavio S Schenkel +6 more
TL;DR: Genotypes for 38,416 markers and August 2003 genetic evaluations for 3,576 Holstein bulls born before 1999 were used to predict January 2008 daughter deviations and genomic prediction improves reliability by tracing the inheritance of genes even with small effects.
Journal ArticleDOI
Hot topic: a unified approach to utilize phenotypic, full pedigree, and genomic information for genetic evaluation of Holstein final score.
TL;DR: A national single-step genetic evaluation with the pedigree relationship matrix augmented with genomic information provided genomic predictions with accuracy and bias comparable to multiple-step procedures and could account for any population or data structure.
Journal ArticleDOI
Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle
Hans D. Daetwyler,Aurélien Capitan,Hubert Pausch,Paul Stothard,Rianne van Binsbergen,R.F. Brøndum,Xiaoping Liao,Anis Djari,Sabrina Rodriguez,Cécile Grohs,Diane Esquerre,Olivier Bouchez,Marie-Noelle Rossignol,Christophe Klopp,Dominique Rocha,Sébastien Fritz,André Eggen,Phil J. Bowman,David Coote,Amanda J. Chamberlain,Charlotte Anderson,Curt P VanTassell,Ina Hulsegge,Michael E. Goddard,Bernt Guldbrandtsen,M.S. Lund,Roel F. Veerkamp,Didier Boichard,Ruedi Fries,Ben J. Hayes +29 more
TL;DR: The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls.
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The QTN Program and the Alleles That Matter for Evolution: All That’s Gold Does Not Glitter
TL;DR: It is argued that neither theory nor data justify a view of readily discoverable large‐effect alleles as the primary molecular substrates for evolution, and that evolution often acts via large numbers of small‐effect polygenes, individually undetectable.
Journal ArticleDOI
Computing procedures for genetic evaluation including phenotypic, full pedigree, and genomic information
TL;DR: The proposed methodology may allow the upgrading of an existing evaluation to incorporate the genomic information when the information attributable to genomics can be expressed as modifications to the numerator relationship matrix.
References
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Generalized Linear Mixed Models in Dairy Cattle Breeding
TL;DR: Steady advances in available computing power have facilitated multiple-trait analyses involving continuous and discrete measures, and full Bayesian inference via the development of Markov Chain Monte Carlo methods will continue to allow even greater generality and dimensions in the genetic model.
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Effects of Body Measurements and Weight on Calf Size and Calving Difficulty of Holsteins
TL;DR: Least squares analysis showed that cows with shorter wither height and shorter pelvises tended to require more calving assistance, and male calves were heavier than female calves and also were associated with greater calving difficulty.
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Factors influencing calving difficulty in beef heifers.
TL;DR: Records of 547, 2-yr-old heifers of three breed groups were used to evaluate the relative influence of dam's body and pelvic measurements, calf birth weight, sire birth weight and some relative measures (ratios) of calf birthWeight and dam weight at calving on calving difficulty.
Journal ArticleDOI
Quantitative trait loci affecting calving traits in Danish Holstein cattle.
TL;DR: Markers on chromosomes 3, 4, 7, 10, 12, 18, 21, 24, 26, and 28 can be used to select new breeding candidates to produce daughters with more efficient calving performance.
Journal ArticleDOI
Identification and molecular characterization of a novel member of the siglec family (SIGLEC9).
George Foussias,George M. Yousef,George M. Yousef,Eleftherios P. Diamandis,Eleftherios P. Diamandis +4 more
TL;DR: It is speculated that this novel siglec-9 gene may also have some utility as a target for immunological antineoplastic therapy and is also conserved in the extracellular Ig-like domains.