Distribution of microRNAs associated with major depressive disorder among blood compartments.
Claudia Homorogan,Virgil Radu Enatescu,Diana Nitusca,Anca Marcu,Edward Seclaman,Catalin Marian +5 more
TLDR
In this paper, major depressive disorder (MDD) is a recurrent disorder with an increasing incidence Alterations in key signaling pathways of the nervous system, such as the Wnt and MAPK pathways.Abstract:
ObjectiveMajor depressive disorder (MDD) is a recurrent disorder with an increasing incidence Alterations in key signaling pathways of the nervous system, such as the Wnt and MAPK pathways, mediatread more
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Extracellular vesicle approach to major psychiatric disorders.
TL;DR: A recent review as discussed by the authors summarizes the findings of studies on extracellular vesicles in major psychiatric disorders, particularly in the field of biomarkers, and discusses the respective therapeutic potential of EVs.
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Is depression the missing link between inflammatory mediators and cancer?
Barbara Politynska,Olga Pokorska,Anna M. Wojtukiewicz,Magdalena Sawicka,M Myśliwiec,Kenneth V. Honn,Stephanie C. Tucker,Marek Z. Wojtukiewicz +7 more
TL;DR: In this paper , it has been demonstrated that inflammation at a peripheral level may be mirrored centrally in astrocytes and microglia serving to promote chronic levels of inflammation in the brain.
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The VEGF protein levels, miR-101-3p, and miR-122-5p are dysregulated in plasma from adolescents with major depression.
M Krivosova,J Adamcakova,Erik Kaadt,Birgitte Hviid Mumm,Dana Dvorská,Dušan Braný,Zuzana Dankova,Matúš Dohál,Marek Samec,N. Ferencova,Ingrid Tonhajzerova,Igor Ondrejka,I Hrtanek,P. Hutka,M. Oppa,Juraj Mokry,Betina Elfving +16 more
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Analyzing real-time PCR data by the comparative C(T) method.
TL;DR: This protocol provides an overview of the comparative CT method for quantitative gene expression studies and various examples to present quantitative gene Expression data using this method.
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Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
TL;DR: Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups.
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Cross-national epidemiology of major depression and bipolar disorder
Myrna M. Weissman,Roger C. Bland,Glorisa Canino,Carlo Faravelli,Steven Greenwald,Hai-Gwo Hwu,Peter R. Joyce,Elie G. Karam,C. K. Lee,Joseph Lellouch,J P Lépine,Stephen C. Newman,Maritza Rubio-Stipec,J. E. Wells,Priya Wickramaratne,Hans-Ulrich Wittchen,E.-K. Yeh +16 more
TL;DR: There are striking similarities across countries in patterns of major depression and of bipolar disorder and the differences in rates for major depression across countries suggest that cultural differences or different risk factors affect the expression of the disorder.
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Hippocampal volume and depression: a meta-analysis of MRI studies.
Poul Videbech,Barbara Ravnkilde +1 more
TL;DR: Hippocampal volume is reduced in patients with unipolar depression, maybe as a consequence of repeated periods of major depressive disorder.