Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade
TLDR
A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS).Abstract:
A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS). These will provide a high degree of applying economical and ecological advantages as well as of practicability. Water, ionic liquids, and solvent-less syntheses as well as use of various forms of energy as microwave and ultrasonic irradiation are examined and discussed.read more
Citations
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Efficient Construction of CN Double Bonds via Acceptorless Dehydrogenative Coupling
Journal ArticleDOI
Ligand-controlled product selectivity in palladium-catalyzed domino post-Ugi construction of (spiro)polyheterocycles.
Zhenghua Li,Nandini Sharma,Upendra K. Sharma,Jeroen Jacobs,Luc Van Meervelt,Erik V. Van der Eycken +5 more
TL;DR: A novel diversity-oriented access to (spiro)polyheterocycles possessing two adjacent quaternary carbon stereocenters is described, by combining an Ugi 4-CR with Pd-catalysis.
Journal ArticleDOI
Nano-Mgo-Catalyzed One-Pot Synthesis of Phosphonate Ester Functionalized 2-Amino-3-Cyano-4H-Chromene Scaffolds at Room Temperature
Goutam Brahmachari,Sujay Laskar +1 more
TL;DR: In this paper, a facile and efficient protocol for one-pot three-component synthesis of structurally diverse (2-amino-3-cyano-4H-chromen-4-yl)phosphonic acid diethyl esters from the reaction of salicylaldehydes, was proposed.
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Diversity-Oriented Synthesis of Furo[3,2-c]coumarins and Benzofuranyl Chromenones through Chemoselective Acylation/Wittig Reaction.
Shu Mei Yang,Chein Yi Wang,Chun Kai Lin,Praneeth Karanam,Ganapuram Madhusudhan Reddy,Yi Ling Tsai,Wenwei Lin +6 more
TL;DR: A highly efficient and chemoselective one-pot protocol for the diversity-oriented synthesis of two types of coumarin-based formal cross-coupling adducts, furo[3,2-c]coumarins and 3-benzofuranyl chromenones, is described.
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Novel magnetic propylsulfonic acid-anchored isocyanurate-based periodic mesoporous organosilica (Iron oxide@PMO-ICS-PrSO3H) as a highly efficient and reusable nanoreactor for the sustainable synthesis of imidazopyrimidine derivatives.
TL;DR: The iron oxide@PMO-ICS-PrSO3H nanomaterials, as a novel and highly efficient recoverable nanoreactor, was investigated for the sustainable heteroannulation synthesis of imidazopyrimidine derivatives through the Traube–Schwarz multicomponent reaction of 2-aminobenzoimidazole, C‒H acids and diverse aromatic aldehydes.
References
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Book
Comprehensive Heterocyclic Chemistry II
TL;DR: In this article, the CHEC III is organized in 15 volumes and closely follows the organization used in the previous edition: Volumes 1 and 2: Cover respectively three and four-membered heterocycles, together with all fused systems containing a three- or four-measured heterocyclic ring.
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Natural product synthesis using multicomponent reaction strategies.
B. Barry Touré,Dennis G. Hall +1 more
TL;DR: The preparation of urea by Wöhler constituted a landmark achievement in organic chemistry, and it laid the ground for the early days of target-oriented organic synthesis, a task deemed inconceivable by early practitioners.
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A Planning Strategy for Diversity‐Oriented Synthesis
TL;DR: Although the distinct goals of DOS do not permit the application of retrosynthetic concepts and thinking, these foundations are being built on, by using parallel logic, to develop a complementary procedure known as forward-Synthetic analysis, which facilitates synthetic planning, communication, and teaching in this evolving discipline.
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Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity
TL;DR: An overview of general strategies that allow the design of novel multicomponent reactions is presented and the challenges and opportunities for the future are discussed.
Journal ArticleDOI
Strategies for Innovation in Multicomponent Reaction Design
TL;DR: This Account provides several examples that illustrate the use of SRR with known MCRs as starting points for synthetic innovation in this area, and explores strategies for engineering improvements into known M CRs, either by increasing the dimensionality, broadening the scope of useful input structures, or both.