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Open AccessJournal ArticleDOI

Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade

Heiner Eckert
- 20 Jan 2012 - 
- Vol. 17, Iss: 1, pp 1074-1102
TLDR
A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS).
Abstract
A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS). These will provide a high degree of applying economical and ecological advantages as well as of practicability. Water, ionic liquids, and solvent-less syntheses as well as use of various forms of energy as microwave and ultrasonic irradiation are examined and discussed.

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Multicomponent reactions in unconventional solvents: state of the art

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Unravelling the labyrinth of palladium-catalysed reactions involving isocyanides

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Multicomponent mechanochemical synthesis

TL;DR: Multicomponent reactions promoted by mechanical energy are critically reviewed and new ideas are proposed to improve the understanding of these reactions.
References
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Journal ArticleDOI

Click Chemistry - What’s in a Name? Triazole Synthesis and Beyond

TL;DR: This review covers reactions included in this label such as cycloadditions, nucleophilic ring-opening reactions of strained cycles, and amide synthesis, as well as their applications in organic synthesis, molecular biology, macromolecular chemistry and materials science.
Journal ArticleDOI

Multiple Multicomponent Macrocyclizations (MiBs) : A Strategic Development Toward Macrocycle Diversity

TL;DR: Combinatorial synthetic chemistry in the macrocycle field does not yet reflect the tremendous impact of naturally occurring macrocycles in areas such as antibiotics, immunosuppressants, ion chelators, or membrane active compounds, where their success rate appears to be overproportional (in relative terms) compared to other drug types.
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