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Open AccessJournal ArticleDOI

Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade

Heiner Eckert
- 20 Jan 2012 - 
- Vol. 17, Iss: 1, pp 1074-1102
TLDR
A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS).
Abstract
A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS). These will provide a high degree of applying economical and ecological advantages as well as of practicability. Water, ionic liquids, and solvent-less syntheses as well as use of various forms of energy as microwave and ultrasonic irradiation are examined and discussed.

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References
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Journal ArticleDOI

New four-component reactions in water: a convergent approach to the metal-free synthesis of spiro[indoline/acenaphthylene-3,4′-pyrazolo[3,4-b]pyridine derivatives

TL;DR: In this article, four-component domino reactions are described that allow the one-pot synthesis of spiro[indoline/acenaphthylene-3,4′-pyrazolo[3, 4-b]pyridine derivatives from the reaction of phenylhydrazine, 3-aminocrotononitrile, isatin/acetyl-1,2-dione, and cyclic 1,3-dicarbonyl compounds.
Journal ArticleDOI

One-step synthesis of 3-aryl- and 3,4-diaryl-(1H)-pyrroles using tosylmethyl isocyanide (TOSMIC).

TL;DR: A one-step synthesis of 3-aryl and 3,4-diaryl-(1H)-pyrroles from TOSMIC and commercially available or readily synthesized arylalkenes is reported.
Journal ArticleDOI

New domino approach for the synthesis of 2,3-disubstituted benzo[b]furans via copper-catalyzed multi-component coupling reactions followed by cyclization

TL;DR: In this paper, an efficient 2,3-disubstituted benzo[b]furans was constructed via copper-catalyzed three-component coupling reactions of salicylaldehydes, amines, and alkynes followed by base-assisted O-annulation reaction.
Journal ArticleDOI

Three-component strategy toward 5-membered heterocycles from isocyanide dibromides.

TL;DR: New cascades were developed involving the addition of a nitrogenated nucleophile-an azide or a tetrazole-on isocyanide dibromides, an electrocyclization, and a Suzuki coupling, which afford new accesses to tetrazoles and triazole scaffolds.
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