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Open AccessJournal ArticleDOI

Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade

Heiner Eckert
- 20 Jan 2012 - 
- Vol. 17, Iss: 1, pp 1074-1102
TLDR
A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS).
Abstract
A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS). These will provide a high degree of applying economical and ecological advantages as well as of practicability. Water, ionic liquids, and solvent-less syntheses as well as use of various forms of energy as microwave and ultrasonic irradiation are examined and discussed.

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References
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Journal ArticleDOI

Copper‐Catalyzed Four‐Component Coupling between Aldehydes, Amines, Alkynes, and Carbon Dioxide

TL;DR: In this paper, a simple and efficient synthesis of oxazolidinones was developed through a copper-catalyzed coupling of aldehydes, amines, and terminal alkynes under atmospheric pressure of carbon dioxide.
Journal ArticleDOI

The efficient one-pot reaction of up to eight components by the union of multicomponent reactions.

TL;DR: A novel approach is reported that combines two or more MCRs in one pot to achieve higher-order M CRs with unprecedented possibilities for complexity generation and diversification.
Journal ArticleDOI

A Copper(I) Isonitrile Complex as a Heterogeneous Catalyst for Azide−Alkyne Cycloaddition in Water

TL;DR: A structurally well-defined copper(I) isonitrile complex is shown to be an efficient, heterogeneous catalyst for the Huisgen azide-alkyne 1,3-dipolar cycloaddition under mild conditions in water.
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