Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade
TLDR
A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS).Abstract:
A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS). These will provide a high degree of applying economical and ecological advantages as well as of practicability. Water, ionic liquids, and solvent-less syntheses as well as use of various forms of energy as microwave and ultrasonic irradiation are examined and discussed.read more
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Journal ArticleDOI
Enantiopure Trisubstituted Tetrahydrofurans with Appendage Diversity: Vinyl Sulfone- and Vinyl Sulfoxide-Modified Furans Derived from Carbohydrates as Synthons for Diversity Oriented Synthesis.
Debanjana Dey,Tanmaya Pathak +1 more
TL;DR: The orientation of the substituents attached at the C-2 position of furans is sufficient to control the diastereoselectivity of the addition of various nucleophiles to the vinyl sulfone/sulfoxide-modified tetrahydrofurans, irrespective of the size of the group.
Book ChapterDOI
Boric Acid: A Versatile Catalyst in Organic Synthesis
Shahebaaz K. Pathan,Paresh R. Mahaparale,Satish U. Deshmukh,Hemant D. Une,Rohidas Arote,Jaiprakash N. Sangshetti +5 more
TL;DR: In this article, the concept of synthesis of organic compounds follows green chemistry principle in order to minimize environmental hazards caused due to organic solvents Thus to implement an environment-friendly approach, researchers stand in a need of water-compatible catalysts.
Journal ArticleDOI
Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi-Component Reactions (MCRs) of the Last Decade
TL;DR: In this paper, a collection of smart multicomponent reactions with continuative post condensation cyclizations (PCCs) is presented to construct conventional three to seven-membered heterocyclic compounds in diversity oriented syntheses.
Journal ArticleDOI
Substrate-dependent regiodivergent three-component condensation of 1H-pyrrole-2,3-diones, malononitrile and 4-hydroxyquinolin-2(1H)-ones
T. V. Sal’nikova,Andrey A. Sabitov,Maksim V. Dmitriev,Andrey N. Maslivets,Michael Rubin,Michael Rubin +5 more
TL;DR: An efficient regiodivergent three-component condensation of 1H-pyrrole-2,3-diones, malononitrile, and 4-hydroxyquinolin-2(1H)-ones was developed in this article.
Journal ArticleDOI
A Catalyst-Free Aqueous Synthesis of 2-Amino-7,9-dihydrothieno[3′,2′:5,6]pyrido[2,3-d]pyrimidine-4,6(3H,5H)-dione Derivatives
TL;DR: In this paper, a series of novel 7,9-dihydrothieno[3′,2′:5,6]pyrido[2,3-d]pyrimidine-4,6(3H,5H)-dione derivatives were synthesized efficiently via the catalyst-free reaction of aldehyde, ethyl 2,4-dioxotetrahydrothiophene-3-carboxylate, and 2,6-diaminopyrimidine -4,3H)-one through the sequence of de
References
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Book
Comprehensive Heterocyclic Chemistry II
TL;DR: In this article, the CHEC III is organized in 15 volumes and closely follows the organization used in the previous edition: Volumes 1 and 2: Cover respectively three and four-membered heterocycles, together with all fused systems containing a three- or four-measured heterocyclic ring.
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B. Barry Touré,Dennis G. Hall +1 more
TL;DR: The preparation of urea by Wöhler constituted a landmark achievement in organic chemistry, and it laid the ground for the early days of target-oriented organic synthesis, a task deemed inconceivable by early practitioners.
Journal ArticleDOI
A Planning Strategy for Diversity‐Oriented Synthesis
TL;DR: Although the distinct goals of DOS do not permit the application of retrosynthetic concepts and thinking, these foundations are being built on, by using parallel logic, to develop a complementary procedure known as forward-Synthetic analysis, which facilitates synthetic planning, communication, and teaching in this evolving discipline.
Journal ArticleDOI
Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity
TL;DR: An overview of general strategies that allow the design of novel multicomponent reactions is presented and the challenges and opportunities for the future are discussed.
Journal ArticleDOI
Strategies for Innovation in Multicomponent Reaction Design
TL;DR: This Account provides several examples that illustrate the use of SRR with known MCRs as starting points for synthetic innovation in this area, and explores strategies for engineering improvements into known M CRs, either by increasing the dimensionality, broadening the scope of useful input structures, or both.